Traumatic brain injury induces adipokine gene expression in rat brain

Neuroscience Letters
Russell BrownMichael Wilkinson

Abstract

Traumatic brain injury (TBI) induces cachexia and neuroinflammation which profoundly impact patient recovery. Adipokine genes such as leptin (ob), resistin (rstn) and fasting-induced adipose factor (fiaf) are implicated in energy metabolism and body weight control and are also associated with chronic low grade inflammation. Since central rstn and fiaf expression was increased following hypoxic/ischemic brain injury, we hypothesized that these genes would also be induced in the rat brain following TBI. Realtime RT-PCR detected a 2-2.5-fold increase in ob mRNA in the ipsilateral cortex and thalamus 12h following lateral fluid percussion (FP)-induced brain injury. Fiaf mRNA was elevated 5-7.5-fold in cortex, hippocampus and thalamus, and modest increases were also detectable in the contralateral brain. Remarkably, rstn mRNA was elevated in ipsilateral (150-fold) and in contralateral (50-fold) hippocampus. To test whether these changes were part of an inflammatory response to TBI we also examined the effects of an intracerebral injection of lipopolysaccharide (LPS). We determined that central injection of LPS produced some, but not all, of the changes seen after TBI. For example, in contrast to the stimulatory influence of TBI, LPS...Continue Reading

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Citations

Oct 30, 2010·Critical Care : the Official Journal of the Critical Care Forum·Xiao-Qiao DongHang-Bin Huang
Feb 2, 2012·General and Comparative Endocrinology·Eric W RoubosLu Xu
Aug 20, 2008·Journal of Neuroscience Research·Naomi L CookCorinna van den Heuvel
Jun 30, 2010·Journal of Neuroendocrinology·B Del Bianco-BorgesC R Franci
Mar 26, 2016·Journal of Neuroinflammation·Avinash ParimisettyChristian Lefebvre d'Hellencourt
Apr 8, 2014·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Ilse A C ArnoldussenDeborah R Gustafson
Aug 22, 2014·Lancet Neurology·Amanda J KiliaanDeborah R Gustafson
Jun 19, 2013·Chinese Journal of Integrative Medicine·Ming ChenJin-Lin Liu
May 19, 2018·Journal of Neurotrauma·Angus G ScrimgeourMarloes J A Joosen
Sep 12, 2012·Neuroreport·Russell E BrownMichael Wilkinson

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