Traumatic brain injury-related inflammatory projection: beyond local inflammatory responses

Acute Medicine & Surgery
Sanae HosomiTakeshi Shimazu

Abstract

Acute neuroinflammation induced by microglial activation is key for repair and recovery after traumatic brain injury (TBI) and could be necessary for the clearance of harmful substances, such as cell debris. However, recent clinical and preclinical data have shown that TBI causes chronic neuroinflammation, lasting many years in some cases, and leading to chronic neurodegeneration, dementia, and encephalopathy. To evaluate neuroinflammation in vivo, positron-emission tomography has been used to target translocator protein, which is upregulated in activated glial cells. Such studies have suggested that remote neuroinflammation induced by regional microglia persists even after reduced inflammatory responses at the injury site. Furthermore, unregulated inflammatory responses are associated with neurodegeneration. Therefore, elucidation of the role of neuroinflammation in TBI pathology is essential for developing new therapeutic targets for TBI. Treatment of associated progressive disorders requires a deeper understanding of how inflammatory responses to injury are triggered, sustained, and resolved and how they impact neuronal function. In this review, we provide a general overview of the dynamics of immune responses to TBI, from a...Continue Reading

References

Jul 19, 2008·Lancet Neurology·Andrew I R MaasRoss Bullock
Jun 29, 2011·Annals of Neurology·Anil F RamlackhansinghDavid J Sharp
Dec 13, 2012·Neuropathology and Applied Neurobiology·C SmithJ A R Nicoll
Dec 19, 2012·Frontiers in Cellular Neuroscience·Zachary R Patterson, Matthew R Holahan
Jan 24, 2013·Neuropathology and Applied Neurobiology·S M Gentleman
Feb 1, 2013·Brain : a Journal of Neurology·Victoria E JohnsonWilliam Stewart
Mar 6, 2013·Nature Reviews. Neurology·Douglas H SmithWilliam Stewart
Jan 28, 2014·Neuron·Joshua E Burda, Michael V Sofroniew
Feb 12, 2014·Nature Reviews. Neurology·David J SharpRobert Leech
May 10, 2014·Annals of Neurology·Peter NordströmAnna Nordström
Jun 14, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Andrea S VincentAlison Cernich
Aug 22, 2014·Journal of Medicinal Chemistry·Markus PielFrank Rösch
Oct 28, 2014·Brain Pathology·Guo-Jun LiuRichard B Banati
Nov 12, 2014·Scientific Reports·Yuki MoriYoshichika Yoshioka
Nov 26, 2014·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Alan I Faden, David J Loane
Sep 8, 2015·Experimental Neurology·David J Loane, Alok Kumar
Oct 20, 2015·Brain Injury : [BI]·Sung Ho Jang, Hyeok Gyu Kwon
Feb 11, 2016·Journal of Biochemistry·Xuemei Jin, Toshihide Yamashita
Mar 18, 2016·ACS Chemical Neuroscience·Daniel S AlbrechtMarco L Loggia
Feb 12, 2017·Nature Reviews. Neurology·Dennis W SimonPatrick M Kochanek
Nov 30, 2019·Frontiers in Neuroscience·Virginie DinetJerome Badaut

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imaging techniques

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Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

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