Traumatic neuroprotection with inhibitors of nitric oxide and ADP-ribosylation

Brain Research
R A WallisJ M Girard

Abstract

N-Methyl-D-aspartate (NMDA) receptor activation is known to contribute to neuronal damage from head trauma. Additionally, NMDA neurotoxicity occurs in part through the generation of nitric oxide (NO), and injury from NO has been shown to be mediated by ADP-ribosylation. Therefore, we investigated whether inhibitors of NO and ADP-ribosylation would protect against acute CA1 traumatic neuronal injury in hippocampal slices subjected to fluid percussion. Treatment with the nitric oxide synthase (NOS) inhibitor, methyl-L-arginine 170 microM for 35 min after trauma injury, improved CA1 antidromic population spike (PS) recovery to 91 +/- 2%, compared to unmediated slices which recovered to only a mean of 20 +/- 4%, 90 min after trauma. Similarly, hemoglobin 50 microM, which directly binds NO, protected against traumatic neuronal injury and yielded a mean CA1 PS recovery of 92 +/- 1%. Treatment with inhibitors of poly-ADP-ribosylation was also strongly protective, with the vitamin nicotinamide 10 mM and 3-aminobenzamide 1 mM yielding PS recoveries of 98 +/- 2% and 90 +/- 3%, respectively. Protection was also seen with inhibitors of mono-ADP-ribosylation, including novobiocin 500 microM and meta-iodobenzylguanidine 20 microM which yield...Continue Reading

References

Apr 1, 1979·Journal of Neurosurgery·H S LevinG Teasdale
Jan 1, 1992·Acta Neuropathologica·M J KotapkaT A Gennarelli
Jul 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·V L DawsonS H Snyder
Aug 15, 1991·Biochemical and Biophysical Research Communications·S Dimmeler, B Brüne
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D S Bredt, S H Snyder
Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·I SakumaR Levi
Jan 1, 1985·Annual Review of Biochemistry·K Ueda, O Hayaishi
Nov 21, 1994·Brain Research·R A WallisJ P Nolan
Jul 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·L J McDonald, J Moss

❮ Previous
Next ❯

Citations

Feb 2, 2013·Molecular Aspects of Medicine·Nicola J Curtin, Csaba Szabo
Feb 5, 2010·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Edward D HallAyman G Mustafa
Aug 15, 1998·Trends in Pharmacological Sciences·C Szabó, V L Dawson
Aug 2, 2003·International Immunopharmacology·Soichi NoguchiTakafumi Kudo
Apr 4, 2013·Antioxidants & Redox Signaling·Carolin CorneliusSalvatore Cuzzocrea
Dec 5, 1998·Journal of Neurotrauma·B MorrisonT K McIntosh
Aug 14, 1999·Journal of Neurotrauma·S N KroppenstedtA W Unterberg
Apr 29, 2009·Journal of Neurotrauma·Yung Chia ChenDavid F Meaney
Aug 24, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M J WhalenP M Kochanek
Sep 29, 2009·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kenneth MaieseYan Chen Shang
Nov 16, 2010·Clinics in Sports Medicine·David F Meaney, Douglas H Smith
Mar 16, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Indrapal N SinghEdward D Hall
Sep 20, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S H LinK Maiese
Sep 10, 2004·The European Journal of Neuroscience·Seong-Ho KohSeung Hyun Kim
Apr 18, 2009·British Journal of Pharmacology·Valerie C Besson
Mar 12, 2010·Journal of Clinical Pharmacology·Kenneth MaieseJinling Hou
Oct 11, 2017·The International Journal of Neuropsychopharmacology·Gregory A OrdwayRussell W Brown
Feb 2, 1999·Neuroreport·K L PanizzonR A Wallis
Jul 11, 2003·Annals of the New York Academy of Sciences·Stephen D Skaper

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.