Trazodone and imipramine: comparative effects on canine cardiac conduction

European Journal of Pharmacology
A W Gomoll, J E Byrne

Abstract

Lead II EKG and His bundle electrograms were recorded in closed-chest pentobarbital-anesthetized dogs. Trazodone, a structurally distinct, new antidepressant agent, had no effect on His--Purkinje (HV interval) or intraventricular (HS interval) conduction following intravenous injection at graded doses between 1 and 30 mg/kg. In contrast, the tricyclic psychotropic agent imipramine (0.5--5 mg/kg) significantly slowed impulse conduction as indicated by increases in both the HV and HS intervals. Imipramine (5 mg/kg) also slowed impulse transmission across the atrium (PA interval). These responses to imipramine were associated with a concurrent prolongation of both the PR interval and QRS duration. In the anesthetized dog, trazodone administration promoted no evidence of heart block or sign of rhythm disturbances other than slowing in normal sinus rhythm.

References

Oct 1, 1976·European Journal of Pharmacology·T BaumD R Much
Mar 1, 1971·Annals of Internal Medicine·R B Williams, C Sherter
Jan 1, 1971·European Journal of Pharmacology·T BaumM I Gluckman
Sep 1, 1969·Toxicology and Applied Pharmacology·A R Laddu, P Somani

❮ Previous
Next ❯

Citations

Jan 1, 1987·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·S A BoschmansS E Terblanche
Jan 1, 1989·Psychological Medicine. Monograph Supplement·S J WarringtonM Lader
Nov 1, 1987·Comprehensive Psychiatry·R Johnson, J Ananth
May 1, 1985·Journal of Clinical Pharmacology·E F Coccaro, L J Siever
Jan 1, 1984·Current Medical Research and Opinion·T J Van de MerweS I Ankier
Sep 1, 1986·Annals of Emergency Medicine·K Kulig
Apr 1, 1983·Annals of Emergency Medicine·T LesarK Saxena
Apr 1, 1988·Journal of Geriatric Psychiatry and Neurology·M A Jenike
Jan 1, 1986·Journal of the American Geriatrics Society·D C Goff, M A Jenike
Jan 1, 1986·The Journal of International Medical Research·P K Mukherjee, A Davey
Jan 1, 1982·Drug Intelligence & Clinical Pharmacy·W N Rawls
Dec 1, 1982·British Journal of Clinical Pharmacology·J F Robinson, D P Doogan
Jun 1, 1981·Life Sciences·M M Al-YassiriP K Bridges

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.