PMID: 7021449Jan 1, 1980Paper

Trazodone in depression

International Pharmacopsychiatry
D Wheatley

Abstract

Dose comparison trials were undertaken with trazodone given once, twice and thrice daily. Therapeutic effects were the same but once daily dosage produced drowsiness whilst thrice daily dosage did not. In a double-blind comparison to imipramine, anti-depressant effects were similar, except at 6 weeks when imipramine was significantly better. There were no significant differences in relief of anxiety symptoms.

Citations

Jan 1, 1982·The Journal of International Medical Research·H H RichardsS Miller
Jun 21, 2012·Expert Opinion on Pharmacotherapy·Letizia BossiniAndrea Fagiolini

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