Treadmill exercise activates ATF3 and ERK1/2 downstream molecules to facilitate axonal regrowth after sciatic nerve injury

Journal of Exercise Rehabilitation
Ji-Eun KimTae-Beom Seo

Abstract

The purpose of this study was to investigate the effect of treadmill exer-cise on activating transcription factors such as activating transcription factor 3 (ATF3) and extracellular signal-regulated kinase (ERK1/2) sig-naling pathway to facilitate axonal regrowth after sciatic nerve injury (SNI). The experimental rats divided into the normal control (n=10), sedentary groups for 7 (n=10) and 14 days (n=10) post crush, exercise group for 7 (n=10) and 14 days (n=10) post crush (dpc). The rats in ex-ercise groups run on treadmill device at a speed of 8 m/min for 20 min once a day according to exercise duration. In order to evaluate specific regeneration markers and axonal elongation in injured sciatic nerve, we applied immunofluorescence staining and western blot techniques. Treadmill exercise further increased growth-associated protein (GAP-43) expression and axonal regrowth at 7 and 14 dpc than those in sed-entary group. Among mitogen-activated protein kinase downstream molecules, phospho-ERK1/2 (p-ERK1/2) was enhanced by treadmill ex-ercise at only 7 dpc and decreased to basal level 14 days later. But c-Jun N-terminal kinase, c-Jun, and phospho-cyclic adenosine mono-phosphate response element-binding protein showed a tendency to...Continue Reading

References

Nov 1, 1994·Trends in Biochemical Sciences·R J Davis
Sep 12, 2001·The International Journal of Biochemistry & Cell Biology·R K Barr, M A Bogoyevitch
Nov 9, 2002·Journal of Neurophysiology·Fernando Gómez-PinillaV Reggie Edgerton
Dec 21, 2005·Acta Pharmacologica Sinica·Tae-beom Seo SeoUk Namgung
Jan 4, 2007·Journal of Cell Science·In Sun HanUk Namgung
Jan 16, 2007·Experimental Neurology·Chun-Jung ChenShan-Hui Hsu
Jul 29, 2008·Current Opinion in Neurobiology·Namiko Abe, Valeria Cavalli
Sep 20, 2008·BMC Neuroscience·Harukazu Saito, Lars B Dahlin
Jun 11, 2009·Journal of Brachial Plexus and Peripheral Nerve Injury·Ali Murat KalenderMahmut Kalender
Mar 25, 2011·British Medical Bulletin·Pilar Martínez de AlbornozNicola Maffulli
Apr 26, 2011·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Esther UdinaXavier Navarro
Jun 16, 2011·Developmental Neurobiology·Darcie L Moore, Jeffrey L Goldberg
Aug 31, 2011·Neural Plasticity·Rosana Macher TeodoriMaria Imaculada de Lima Montebelo
Mar 1, 2012·Frontiers in Molecular Neuroscience·Smriti Patodia, Gennadij Raivich
Apr 12, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jennifer C WilhelmArthur W English
May 23, 2012·Progress in Neurobiology·Ilary AllodiXavier Navarro
Jul 31, 2013·Current Opinion in Neurobiology·Thomas D Glenn, William S Talbot
Oct 8, 2013·International Review of Neurobiology·Paulo A S Armada-da-SilvaAntónio P Veloso
Oct 3, 2014·BioMed Research International·D Grinsell, C P Keating
Apr 24, 2015·Exercise and Sport Sciences Reviews·Manning J Sabatier, Arthur W English
Jan 13, 2016·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Tessa Gordon
Nov 20, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Rodrigo Fernández-VerdejoMarc Francaux
May 16, 2017·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Jianzhong CuiJunling Gao

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Jan 1, 2021·Cells·Vasileios KampanisRadhika Puttagunta

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