Treadmill exercise ameliorates depressive symptoms through increasing serotonin expression in postpartum depression rats

Journal of Exercise Rehabilitation
Eun-Sang JiKijeong Kim

Abstract

Postpartum depression (PPD) is defined as the depressive symptoms that occur from the moment of delivery until 12 months after delivery. PPD symptoms are closely associated with reduced activity of the serotonergic system. Serotonin (5-hydroxytryptamine, 5-HT) plays an important role in the pathogenesis of depression. Tryptophan hydroxylase (TPH) catalyzes the rate-limiting step of 5-HT biosynthesis in the serotonergic neurons. Exercise exerts anti-depressive effect on depression patients as well as on animal models of depression. In the present study, the effect of treadmill exercise on PPD was investigated using rats. For this study, open field test for activity and forced swimming test for depressive symptoms, and immunohistochemistry for 5-HT and TPH were conducted. The rats in the exercise groups were forced to run on a motorized treadmill for 30 min once a day for 2 weeks. Activity in the open field test was decreased in the postpartum rats, however, performing treadmill running increased activity in the postpartum rats. The climbing time was decreased and the immobility time was increased in the postpartum rats. Treadmill exercise increased climbing time and suppressed immobility time in the postpartum rats. 5-HT and TPH...Continue Reading

References

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Jul 6, 2010·Pharmacology, Biochemistry, and Behavior·R M CraftK T Tsutsui
Nov 28, 2013·Journal of Exercise Rehabilitation·Sang-Won LeeChang-Ju Kim
May 29, 2014·Behavioural Brain Research·Leila ArbabiSani Ismaila Muhammad
Jul 2, 2014·Behavioural Brain Research·Jamie Winderbaum FernandezLynn Wecker
Sep 23, 2016·Journal of Exercise Rehabilitation·Joo Hwan RohKhae Hawn Kim

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Citations

Nov 7, 2018·International Neurourology Journal·Eun-Jin MoonJae-Woo Yi
Oct 18, 2020·Brain Sciences·Nurul Uyun Abdul AzizMohamad Taufik Hidayat Baharuldin

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