Treadmill exercise delays the onset of non-motor behaviors and striatal pathology in the CAG140 knock-in mouse model of Huntington's disease

Neurobiology of Disease
D P StefankoM W Jakowec

Abstract

Depression, cognitive impairments, and other neuropsychiatric disturbances are common during the prodromal phase of Huntington's disease (HD) well before the onset of classical motor symptoms of this degenerative disorder. The purpose of this study was to examine the potential impact of physical activity in the form of exercise on a motorized treadmill on non-motor behavioral features including depression-like behavior and cognition in the CAG140 knock-in (KI) mouse model of HD. The CAG140 KI mouse model has a long lifespan compared to other HD rodent models with HD motor deficits emerging after 12months of age and thus provides the opportunity to investigate early life interventions such as exercise on disease progression. Motorized treadmill running was initiated at 4weeks of age (1h per session, 3 times per week) and continued for 6months. Non-motor behaviors were assessed up to 6months of age and included analysis of depression-like behavior (using the tail-suspension and forced-swim tests) and cognition (using the T-maze and object recognition tests). At both 4 and 6months of age, CAG140 KI mice displayed significant depression-like behavior in the forced swim and tail suspension tests and cognitive impairment by deficits ...Continue Reading

Citations

Mar 28, 2018·CNS Neuroscience & Therapeutics·Anton Reiner, Yun-Ping Deng
Jul 25, 2018·Current Protocols in Neuroscience·Claudia Rangel-Barajas, George V Rebec
Sep 7, 2018·Neural Plasticity·Cristine de Paula Nascimento-CastroPatricia S Brocardo
Jun 17, 2019·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Remya R NairElizabeth M C Fisher
Feb 19, 2019·Journal of Huntington's Disease·Filipe B RodriguesEdward J Wild
Jan 11, 2020·Journal of Sport and Health Science·Shanshan GuoTiemin Liu
May 13, 2021·Ageing Research Reviews·Chia-Lung Chuang, Fabio Demontis

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