Treadmill exercise improves motor and memory functions in cerebral palsy rats through activation of PI3K-Akt pathway

Journal of Exercise Rehabilitation
Sun-Young Jung, Dae-Young Kim

Abstract

Cerebral palsy (CP) is a chronic disorder characterized by physical disability and disruption of brain function. We evaluated the effects of treadmill exercise on motor and memory functions in relation with phosphatidylinositol 3-kinase (PI3K)-Akt pathway using CP rat model. Rota-rod test, step-down avoidance task, 5-bromo-2'-deoxyuridine (BrdU) immunohistochemistry, and western blot for synapsin I, postsynaptic density-95 (PSD-95), PI3K, Akt, and glycogen synthase kinase-3β (GSK-3β) were performed. CP was induced by maternal lipopolysaccharide (LPS)-injection with sensorimotor restriction. Five weeks after birth, the rats in the exercise groups were made to run on the treadmill for 30 min per one day, 5 times a week, during 4 weeks. Motor and memory functions were impaired in the LPS-induced CP rats and tread-mill exercise increased motor and memory functions in the CP rats. Cell proliferation in the hippocampus was suppressed in the LPS-induced CP rats and treadmill exercise increased hippocampal cell proliferation in the CP rats. Expressions of synapsin I, PSD-95, phosphorylated (p)-PI3K, and p-Akt were decreased in the LPS-induced CP rats and treadmill exercise enhanced the expressions of synapsin I, PSD-95, p-PI3K, and p-A...Continue Reading

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Citations

Nov 7, 2018·International Neurourology Journal·Jae-Min LeeKhae Hawn Kim
Dec 5, 2019·International Neurourology Journal·Mia KimSang-Seo Park
Nov 18, 2018·Metabolic Brain Disease·Zahra JahangiriMahmoud Hosseini
Jan 9, 2021·Neural Plasticity·Matheus Santos de Sousa FernandesTony Meireles Santos
May 5, 2021·Nature Communications·A FloridoR Andero

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Methods Mentioned

BETA
electrophoresis

Software Mentioned

SPSS Statistics
Pro Plus
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