Treadmill exercise is associated with reduction of reactive microgliosis and pro-inflammatory cytokine levels in the hippocampus of type 2 diabetic rats

Neurological Research
Dae Young YooIn Koo Hwang

Abstract

In the present study, we investigated the effects of treadmill exercise on microglial activation and the subsequent release of tumour necrosis factor-alpha (TNF-alpha), interleukin (IL)-6 and IL-1-beta in the hippocampus in a rat model of type 2 diabetes. At 30 weeks of age, diabetic (Zucker diabetic fatty, ZDF) rats and their littermate control (Zucker lean control, ZLC) rats were either placed on a stationary treadmill or made to run for 1 hour/day at 12-16 m/minute on five consecutive days, for 10 weeks. Once the rats reached 40 weeks, they were perfused and their hippocampus collected for immunohistochemistry or hippocampus collected fresh for the Western blotting or enzyme-linked immunosorbent assay (ELISA). The whole blood glucose levels in exercised ZDF rats were significantly higher than in the sedentary or exercised ZLC rats, but were significantly lower than in the sedentary ZDF rats. In the sedentary ZLC and exercised ZLC rats, ionised calcium-binding adapter molecule 1 (Iba-1) immunoreactive microglia showed normal morphology which had small cytoplasm with ramified processes. In the sedentary ZDF rats, some Iba-1 immunoreactive microglia showed abnormal morphology which had hypertrophied cytoplasm with retracted pro...Continue Reading

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Citations

May 29, 2016·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Xingrui GongMazhong Zhang
Sep 21, 2018·The International Journal of Neuroscience·Bina Kumari MehtaSugato Banerjee
Apr 12, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Masoud RahmatiFarzaneh Chehelcheraghi

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