Treadmill exercise with bone marrow stromal cells transplantation facilitates neuroprotective effect through BDNF-ERK1/2 pathway in spinal cord injury rats

Journal of Exercise Rehabilitation
You-Mi KimEun-Sang Ji

Abstract

Transplantation of bone marrow stromal cells (BMSCs) has been known as one of the effective therapeutic methods for functional recovery of spinal cord injury (SCI). Treadmill exercise also facilitates the functional recovery of SCI. Previously, we reported that combination of BMSCs transplantation with treadmill exercise potentiated the locomotor function in SCI rats. In the present study, we investigated whether recovery effect of BMSCs transplantation or treadmill exercise appears through the brain-derived neurotrophic factor (BDNF)-extracellular signal-regulated kinases 1/2 (ERK1/2) pathway. The spinal cord contusion injury was performed at the T9-T10 level using the impactor. Cultured BMSCs were transplanted directly into the lesion 1 week after SCI. Treadmill exercise was performed 6 days per a week for 6 weeks. Western blot for Bax, Bcl-2, BDNF, tyrosine kinase B (TrkB), and phosphorylated ERK1/2 (p-ERK1/2), phosphorylated JNK was performed. In the present results, combination of BMSCs transplantation with tread-mill exercise potently decreased Bax expression, potently increased Bcl-2 expression, and potently enhanced BDNF and TrkB expressions in the injured spinal cord. Combination of BMSCs transplantation with treadmill...Continue Reading

Citations

Dec 20, 2019·Animal Cells and Systems·Lakkyong HwangJae-Woo Yi
Dec 5, 2019·International Neurourology Journal·Mia KimSang-Seo Park
Jun 3, 2020·International Neurourology Journal·Ju Yeon BanSu Kang Kim
Dec 4, 2020·International Neurourology Journal·Jeong Ho RhoJin Hee Han
Dec 4, 2020·International Neurourology Journal·Seunghwan LeeSunhyung Joo
Nov 24, 2021·Molecular Neurobiology·Katarina Kiss BimbovaNadezda Lukacova

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