Treadmill training-induced adaptations in muscle phenotype in persons with incomplete spinal cord injury

Muscle & Nerve
Brian G StewartS M Phillips

Abstract

Body weight-supported treadmill (BWST) training has been shown to improve ambulatory capacity in persons with a spinal cord injury (SCI); however, the effect that BWST training has on skeletal muscle phenotype is unknown. We aimed to determine whether 6 months (three sessions/week) of BWST training in neurologically stable persons with a traumatic spinal cord injury (ASIA C) alters skeletal muscle phenotype, ambulatory capacity, and blood lipid profile. Externally supported body weight decreased, and walking velocity and duration of the training sessions increased (all P < 0.05) as a result of training. Muscle biopsies revealed increases in the mean muscle-fiber area of type I and IIa fibers. Training induced a reduction in type IIax/IIx fibers, as well as a decrease in IIX myosin heavy chain, and an increase in type IIa fibers. Maximal citrate synthase and 3-hydroxy-acyl-CoA dehydrogenase activity also increased following training. BWST training brought about reductions in plasma total (-11%) and low-density lipoprotein (-13%) cholesterol. We conclude that, in patients with a spinal cord injury, BWST training is able to induce an increase in muscle fiber size and bring about increases in muscle oxidative capacity. In addition,...Continue Reading

References

Feb 1, 1989·Medicine and Science in Sports and Exercise·S P Hooker, C L Wells
Nov 1, 1988·The American Journal of Physiology·T P MartinV R Edgerton
Jul 1, 1988·The American Journal of Physiology·T P MartinV R Edgerton
Mar 1, 1982·The American Journal of Physiology·C S HintzO H Lowry
Apr 1, 1995·The European Journal of Neuroscience·A WernigE Cagol
Jan 1, 1994·European Journal of Applied Physiology and Occupational Physiology·A C FryR S Staron
Jun 1, 1993·Journal of the Neurological Sciences·J M RoundD A Jones
Jan 1, 1996·The American Journal of Physiology·B IllekT E Machen
Jan 14, 1999·Journal of Applied Physiology·M J CastroG A Dudley
Feb 20, 1999·Archives of Physical Medicine and Rehabilitation·H BarbeauA Leroux
May 25, 1999·Spinal Cord·E A Hillegass, G A Dudley
Sep 14, 1999·European Journal of Applied Physiology and Occupational Physiology·M J CastroG A Dudley
Sep 14, 1999·European Journal of Applied Physiology and Occupational Physiology·G A DudleyD F Apple
Apr 18, 2000·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·R S StaronK Toma
Jan 4, 2001·European Journal of Applied Physiology·R M CrameriJ R Sutton
Jun 22, 2001·European Journal of Applied Physiology·M KjaerJ Bangsbo
Oct 6, 2001·The Journal of Spinal Cord Medicine·M S NashR B Goldberg
Oct 18, 2002·Scandinavian Journal of Medicine & Science in Sports·R M CrameriJ R Sutton
Nov 1, 2002·American Journal of Physical Medicine & Rehabilitation·V Reggie EdgertonRyan J Monti

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Citations

Aug 21, 2009·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Christophe M R LeMoineGrant B McClelland
Sep 15, 2006·European Journal of Applied Physiology·Sarah B WilkinsonStuart M Phillips
Jan 10, 2006·Journal of Neurologic Physical Therapy : JNPT·Laurent J Bouyer
May 10, 2008·International Journal of Rehabilitation Research. Internationale Zeitschrift Für Rehabilitationsforschung. Revue Internationale De Recherches De Réadaptation·Daniela Cristina Carvalho de AbreuFernando Cendes
Jun 14, 2006·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Lora M GiangregorioNeil McCartney
Oct 4, 2012·The Journal of Spinal Cord Medicine·Jaynie F Yang, Kristin E Musselman
Jun 21, 2008·Journal of Rehabilitation Research and Development·Michael J McKenzieCharlene E Hafer-Macko
Jun 21, 2008·Journal of Rehabilitation Research and Development·Charlene E Hafer-MackoRichard F Macko
Apr 2, 2014·Journal of Neuroengineering and Rehabilitation·Deborah VaroquiMehdi M Mirbagheri
Sep 16, 2008·Clinical Orthopaedics and Related Research·Daniela Cristina Carvalho de AbreuFernando Cendes
Jun 23, 2010·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Emil KostovskiNils Hjeltnes
May 26, 2011·The Journal of Physiology·Christopher K ThompsonT George Hornby
Aug 28, 2012·Archives of Physical Medicine and Rehabilitation·Susan J HarkemaAndrea L Behrman
Aug 26, 2009·Muscle & Nerve·Bo Biering-SørensenFin Biering-Sørensen
Jul 1, 2007·Topics in Spinal Cord Injury Rehabilitation·Darren E R WarburtonUNKNOWN the SCIRE Research Team
Dec 15, 2010·Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology·Sujin HwangChung-Hwi Yi
Oct 21, 2016·Journal of Neurotrauma·Marie-Pascale CôtéMichel A Lemay
Jan 14, 2017·Disability and Rehabilitation·Hardeep SinghKristin E Musselman
Jul 30, 2005·The Journal of Physiology·Paul L KimStuart M Phillips
Apr 27, 2004·Journal of Applied Physiology·Stuart M PhillipsMark A Tarnopolsky
May 9, 2018·Neurochemical Research·Caroline Cunha do Espírito SantoJocemar Ilha
Jun 9, 2018·International Journal of Molecular Sciences·Dana M OtzelJoshua F Yarrow
Nov 23, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jason E TangStuart M Phillips
Feb 10, 2018·Spinal Cord Series and Cases·Hardeep SinghKristin E Musselman
Dec 13, 2018·European Journal of Applied Physiology·Ashraf S GorgeyZachary A Graham
Apr 6, 2021·Topics in Spinal Cord Injury Rehabilitation·David W McMillanDavid R Gater
May 6, 2021·American Journal of Physiology. Cell Physiology·Zachary A GrahamMarcas M Bamman
Jul 28, 2021·Journal of Neurotrauma·Abdullah A AlrashidiAndrei V Krassioukov

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