PMID: 9163262Mar 1, 1997Paper

Treament of morphine-induced constipation with oral naloxone

Der Anaesthesist
L LataschI Jurna

Abstract

Almost all patients treated with opioids suffer from constipation. Numerous laxatives are used to overcome the problem, but none has yet been found to yield favourable results in all patients. Several studies have attempted to reverse opioid-induced constipation by the use of oral naloxone. Experiments carried out in rats showed that morphine-induced constipation is reduced by oral naloxone without impairment of antinociception [4]. However, evaluation of clinical studies reveals that there is uncertainty about the dosage regimen (the daily dose of naloxone ranged from 0.5% to about 60% that of morphine) and a lack of larger numbers of patients studied. Fifteen patients suffering from opioid-induced constipation participated in the present study. Constipation had been present for 5 to 14 days despite the use of laxatives. According to the results obtained in the animal experiments [4], it was originally planned to administer oral naloxone at a dose ratio of 1:1 with respect to morphine on day 1 and 2; reducing it on day 3 and 4 to one-half and then to one-fourth of the initial dose on day 5 and 6. Twelve patients experienced a strong laxative effect with spontaneous bowel evacuation 1 to 4 h after the first intake of oral nalox...Continue Reading

Citations

May 16, 2006·Digestive Diseases·Anthony Lembo
Jan 1, 2013·Journal of Drug Assessment·Eugene R ViscusiTong J Gan
Dec 22, 1999·Pain·W MeissnerK Reinhart
Dec 25, 2003·Anesthesia and Analgesia·John J BatesDamian B Murphy
Apr 22, 2008·The Cochrane Database of Systematic Reviews·E D McNicolD B Carr
Mar 29, 2013·Expert Opinion on Drug Safety·Mellar DavisPam Gamier
Oct 7, 2015·Journal of Palliative Medicine·Andrew Badke, Drew A Rosielle
Mar 9, 2004·Der Schmerz·A SchwarzerE Klaschik
Oct 31, 2008·Journal of Palliative Medicine·Jay R ThomasNeal E Slatkin
Dec 5, 2008·Wiener medizinische Wochenschrift·Jürgen Osterbrink, Ute Haas
Jun 11, 2015·Scandinavian Journal of Gastroenterology·Bishal GyawaliYuichi Ando
Aug 29, 2002·Alimentary Pharmacology & Therapeutics·N D HawkesG A O Thomas
May 1, 2001·Alimentary Pharmacology & Therapeutics·N D HawkesG A Thomas
Feb 5, 2010·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Imad F BtaicheMichael D Kraft
May 30, 2008·The New England Journal of Medicine·Jay ThomasRobert J Israel

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

Related Papers

The American Journal of Geriatric Pharmacotherapy
Christine M RubyJoseph T Hanlon
Nederlands tijdschrift voor geneeskunde
J Schoorl, Z Zylicz
Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Nancy M TofilMargaret K Winkler
© 2021 Meta ULC. All rights reserved