TREAT AF (Transcutaneous Electrical Vagus Nerve Stimulation to Suppress Atrial Fibrillation): A Randomized Clinical Trial.

JACC. Clinical Electrophysiology
Stavros StavrakisSunny S Po


This study was a sham-controlled, double-blind, randomized clinical trial to examine the effect of chronic low level tragus stimulation (LLTS) in patients with paroxysmal AF. Low-level transcutaneous electrical stimulation of the auricular branch of the vagus nerve at the tragus (LLTS) acutely suppresses atrial fibrillation (AF) in humans, but the chronic effect remains unknown. LLTS (20 Hz, 1 mA below the discomfort threshold) was delivered using an ear clip attached to the tragus (active arm) (n = 26) or the ear lobe (sham control arm) (n = 27) for 1 h daily over 6 months. AF burden over 2-week periods was assessed by noninvasive continuous electrocardiogram monitoring at baseline, 3 months, and 6 months. Five-minute electrocardiography and serum were obtained at each visit to measure heart rate variability and inflammatory cytokines, respectively. Baseline characteristics were balanced between the 2 groups. Adherence to the stimulation protocol (≤4 sessions lost per month) was 75% in the active arm and 83% in the control arm (p > 0.05). At 6 months, the median AF burden was 85% lower in the active arm compared with the control arm (ratio of medians: 0.15; 95% confidence interval: 0.03 to 0.65; p = 0.011). Tumor necrosis fact...Continue Reading


Feb 9, 2002·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Elmar T Peuker, Timm J Filler
Nov 19, 2003·Circulation·Ronnier J AvilesMina K Chung
Feb 9, 2006·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Roy Freeman
Feb 4, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Youhua ZhangTodor N Mazgalev
Feb 28, 1930·The Journal of Experimental Medicine·E C AndrusUNKNOWN With an Appendix by Harold A. Wheeler, Ph.D
Jun 2, 2010·Cellular & Molecular Immunology·Youcun QianXiaoxia Li
Apr 15, 2011·Journal of Cardiovascular Electrophysiology·Yong ShaSunny S Po
Dec 15, 2012·Acta Oto-laryngologica·Jarmo LehtimäkiJukka Ylikoski
Dec 18, 2012·Pacing and Clinical Electrophysiology : PACE·Michael A RosenbergPeter J Zimetbaum
Apr 26, 2014·Circulation Research·Peng-Sheng ChenStanley Nattel
Aug 29, 2014·Brain Stimulation·Jennifer A ClancyJim Deuchars
Sep 6, 2014·Cold Spring Harbor Perspectives in Biology·Toshio TanakaTadamitsu Kishimoto
Jan 28, 2015·Nature Reviews. Cardiology·Yu-Feng HuShih-Ann Chen
Mar 10, 2015·Journal of the American College of Cardiology·Stavros StavrakisSunny S Po
Jul 21, 2015·Acta Neurologica Scandinavica·T J M VerlindenA Herrler
Jul 7, 2016·Proceedings of the National Academy of Sciences of the United States of America·Frieda A KoopmanPaul P Tak
Jun 22, 2017·Immunity·Sangeeta S ChavanKevin J Tracey
Apr 5, 2018·Frontiers in Physiology·Jesse L AshtonJohanna M Montgomery
Apr 18, 2018·Circulation·Lin Y ChenUNKNOWN American Heart Association Council on Clinical Cardiology; Council on Cardiovascular and Stroke Nursing; Council on Quality
Apr 21, 2018·Annual Review of Immunology·Valentin A PavlovKevin J Tracey
Jun 29, 2018·Frontiers in Aging Neuroscience·Joyce Gomes-OsmanAdam J Woods
Dec 19, 2018·Journal of Cardiovascular Translational Research·Nicole TranStavros Stavrakis
Apr 7, 2019·Epilepsy Research·Hajo M Hamer, Sebastian Bauer

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