Nov 22, 2014

Treating atherosclerosis with regulatory T cells

Arteriosclerosis, Thrombosis, and Vascular Biology
Amanda C FoksJohan Kuiper

Abstract

Regulatory T cells (Tregs) play an important role in the regulation of T-cell-mediated immune responses through suppression of T-cell proliferation and secretion of inhibitory cytokines, such as interleukin-10 and transforming growth factor-β. Impaired Treg numbers and function have been associated with numerous diseases, and an imbalance between proinflammatory/proatherogenic cells and Tregs promotes atherosclerotic disease. Restoration of this balance by inducing Tregs has great therapeutic potential to prevent cardiovascular disease. In addition to suppressing differentiation and function of effector T cells, Tregs have been shown to induce anti-inflammatory macrophages, inhibit foam cell formation and to influence cholesterol metabolism. Furthermore, Tregs suppress immune responses of endothelial cells and innate lymphoid cells. In this review, we focus on the recent knowledge on Treg subsets, their activity and function in atherosclerosis, and discuss promising strategies to use Tregs as a therapeutic tool to prevent cardiovascular disease.

  • References78
  • Citations44

References

Mentioned in this Paper

Recombinant Transforming Growth Factor
Immune Response
Immunomodulators
T-Lymphocyte
Cholesterol Metabolic Process
Imbalance
Inflammation Mediators
Recombinant Interleukin-10
Anti-Inflammatory Agents
Lymphoid Cells

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