Treating cocaine addiction with viruses

Proceedings of the National Academy of Sciences of the United States of America
M Rocio A CarreraKim D Janda

Abstract

Cocaine addiction continues to be a major health and social problem in the United States and other countries. Currently used pharmacological agents for treating cocaine abuse have proved inadequate, leaving few treatment options. An alternative is to use protein-based therapeutics that can eliminate the load of cocaine, thereby attenuating its effects. This approach is especially attractive because the therapeutic agents exert no pharmacodynamic action of their own and therefore have little potential for side effects. The effectiveness of these agents, however, is limited by their inability to act directly within the CNS. Bacteriophage have the capacity to penetrate the CNS when administered intranasally. Here, a method is presented for engineering filamentous bacteriophage to display cocaine-binding proteins on its surface that sequester cocaine in the brain. These antibody-displaying constructs were examined by using a locomotor activity rodent model to assess the ability of the phage-displayed proteins to block the psychoactive effects of cocaine. Results presented demonstrate a strategy in the continuing efforts to find effective treatments for cocaine addiction and suggest the application of this protein-based treatment fo...Continue Reading

References

Nov 1, 1992·Archives of General Psychiatry·I O ArndtC P O'Brien
Feb 4, 1989·Lancet·P BergerT R Kosten
Feb 4, 1989·Lancet·J C WilliamsN J Maitland
Oct 1, 1989·Biological Psychiatry·T R KostenC Morgan
Jan 1, 1987·Archives of Internal Medicine·F S Tennant, A A Sagherian
Apr 1, 1987·Psychiatry Research·C A DackisR Climko
Feb 1, 1995·Journal of Clinical Psychopharmacology·N W WithersJ C Gillin
Mar 26, 1993·Science·D W LandryT M Georgiadis
Apr 11, 1996·The New England Journal of Medicine·J H Mendelson, N K Mello
Mar 28, 1996·Nature·R Pasqualini, E Ruoslahti
Oct 1, 1996·Nature Medicine·B S FoxT J Briner
Aug 1, 1997·Toxicology and Applied Pharmacology·C E MattesK L Dretchen
Oct 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·C GaoK D Janda
Feb 4, 1998·Drug and Alcohol Dependence·D A Gorelick
May 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·C GaoK D Janda
May 24, 2000·Proceedings of the National Academy of Sciences of the United States of America·M R CarreraK D Janda
Feb 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·M R CarreraK D Janda
Feb 24, 2001·Bioorganic & Medicinal Chemistry Letters·M MatsushitaK D Janda
Aug 23, 2001·Advanced Drug Delivery Reviews·N Jones
Aug 23, 2001·Advanced Drug Delivery Reviews·S S Davis
Aug 23, 2001·Advanced Drug Delivery Reviews·L IllumS S Davis
Feb 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Markus Essler, Erkki Ruoslahti
Mar 9, 2002·Current Pharmaceutical Biotechnology·David LaroccaAndrew Baird
Apr 4, 2002·Journal of the American Chemical Society·Shigeki IsomuraKim D Janda
Apr 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Dan Frenkel, Beka Solomon
Jul 20, 2002·Molecular Pharmacology·Hong SunStephen Brimijoin
Sep 20, 2002·Proceedings of the National Academy of Sciences of the United States of America·Changshou GaoKim D Janda
Oct 29, 2003·Journal of Immunological Methods·Jason A MossKim D Janda
Feb 14, 2006·Current Drug Discovery Technologies·Michael M MeijlerKim D Janda

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Citations

Feb 3, 2009·Clinical and Experimental Medicine·Aneta KurzepaAndrzej Górski
Nov 9, 2007·Journal of Computer-aided Molecular Design·Fang Zheng, Chang-Guo Zhan
Apr 23, 2005·Virus Research·Ryszard MiedzybrodzkiAndrzej Gorski
Jul 14, 2005·Journal of the American Chemical Society·Claude J RogersKim D Janda
Aug 20, 2008·Journal of the American Chemical Society·Fang ZhengChang-Guo Zhan
Jun 18, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Laying WuQian Wang
Apr 1, 2009·Immunology and Cell Biology·Berma M KinseyFrank M Orson
May 4, 2010·Protein Engineering, Design & Selection : PEDS·Diwahar NarasimhanRoger K Sunahara
Jul 4, 2008·Neuroreport·Michael R Tilley, Howard H Gu
Dec 22, 2004·Journal of Applied Microbiology·K DabrowskaA Gorski
Jul 28, 2004·Proceedings of the National Academy of Sciences of the United States of America·David Nutt, Anne Lingford-Hughes
Nov 9, 2005·Proceedings of the National Academy of Sciences of the United States of America·Yongmei PanChang-Guo Zhan
Oct 8, 2011·Frontiers of Materials Science·Yiyang Lin, Chuanbin Mao
Jun 15, 2005·Expert Opinion on Biological Therapy·Tobin J DickersonKim D Janda
Apr 8, 2009·Pharmacology, Biochemistry, and Behavior·Amira Y Moreno, Kim D Janda
Mar 1, 2009·Microbial Biotechnology·Fabrizio Arigoni, Harald Brüssow
Dec 9, 2014·The Biochemical Journal·Xiabin ChenChang-Guo Zhan
Aug 22, 2012·Human Vaccines & Immunotherapeutics·Justyna BazanAndrzej Gamian
Jan 12, 2010·Chemico-biological Interactions·Wenchao YangChang-Guo Zhan
Dec 12, 2013·Molecular BioSystems·Lei FangChang-Guo Zhan
Sep 1, 2017·Immunological Reviews·Jeremy J Barr
Feb 6, 2018·Scientific Reports·Li MaAnthony W Maresso
Aug 8, 2009·Angewandte Chemie·Chuanbin MaoBinrui Cao
Feb 23, 2008·Organic & Biomolecular Chemistry·Fang Zheng, Chang-Guo Zhan
Mar 1, 2008·Expert Review of Clinical Pharmacology·David A Gorelick
Oct 1, 2013·Organic & Biomolecular Chemistry·Shurong HouChang-Guo Zhan
Feb 27, 2020·Organic & Biomolecular Chemistry·Xirong ZhengFang Zheng
Mar 11, 2005·Expert Review of Vaccines·Karen Manoutcharian
Aug 14, 2008·The Journal of Pharmacology and Experimental Therapeutics·Michael R Tilley, Howard H Gu
Sep 10, 2020·Vaccines·Alejandro González-MoraJorge Benavides
Jun 27, 2019·Biomedicines·Gerald F AudetteRaj Bawa
Jan 14, 2017·Brain : a Journal of Neurology·Primavera A Spagnolo, David Goldman

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