Treating colon cancers with a non-conventional yet strategic approach: An overview of various nanoparticulate systems.

Journal of Controlled Release : Official Journal of the Controlled Release Society
N A Bhaskaran, L Kumar

Abstract

Regardless of progress in therapy management which are developed for colon cancer (CC), it remains the third most common cause of mortality due to cancers around the world. Conventional medicines pose side effects due to untoward action on non-target cells. Their inability to deliver drugs to the affected regions of the colon locally, in a reproducible manner raises a concern towards the efficacy of therapy. In this regard, nanoparticles emerged as a promising drug delivery system due to their flexibility in designing, drug release modulation and cancer cell targeting. Not only are nanoparticles making their way into colon cancer research in the revolution of conventional onco-therapeutics, but they also offer promising scope in the development of colon cancer vaccines and theranostic tools. However, there are challenges with respect to drug delivery using nanoparticles, which may hamper the delivery of these novel carriers to the colon. The present review addresses recent advents in nanotechnology for colon-specific drug delivery (CDDS) which may help to overcome the existing challenges and intends to recognize futuristic potentials in the treatment of CC with CDDS.

References

Jun 1, 1990·Cell·E R Fearon, B Vogelstein
Feb 8, 1990·The New England Journal of Medicine·C G MoertelJ H Glick
Oct 1, 1996·Diseases of the Colon and Rectum·E L BokeyR C Newland
May 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·S K HobbsR K Jain
Aug 19, 2000·Diseases of the Colon and Rectum·S C BarrancoP Kolm
Mar 10, 2001·American Journal of Clinical Oncology·A F ShieldsM M Zalupski
Mar 29, 2001·Proceedings of the National Academy of Sciences of the United States of America·A PluenR K Jain
Apr 3, 2001·Nature Biotechnology·R Weissleder
Mar 27, 2002·Cancer Chemotherapy and Pharmacology·Lalitha IyerUlrich Mayer
Aug 9, 2003·Cancer Chemotherapy and Pharmacology·Akinobu KuritaTeruo Yokokura
Oct 22, 2003·Pharmaceutical Research·Xuan ChengMaria A Croyle
Feb 3, 2004·The Oncologist·Amna IbrahimRichard Pazdur
Jun 4, 2004·The New England Journal of Medicine·Herbert HurwitzFairooz Kabbinavar
Jan 5, 2005·Nature Reviews. Cancer·Bruce A Chabner, Thomas G Roberts
Aug 25, 2005·IEEE Transactions on Nanobioscience·Niraj Sinha, John T W Yeow
Sep 1, 2005·Molecular and Cellular Biochemistry·Izabela DobrzyńskaZbigniew Figaszewski
Nov 24, 2005·International Journal of Pharmaceutics·Donald E Owens, Nicholas A Peppas
Mar 22, 2006·Proceedings of the National Academy of Sciences of the United States of America·Julie A Champion, Samir Mitragotri
Mar 22, 2006·Pharmaceutical Research·Mohamed Nabil KhalidJean-Christophe Leroux
Oct 20, 2006·Expert Opinion on Biological Therapy·Zev Wainberg, J Randolph Hecht
Apr 19, 2007·Nano Letters·Sonia KumarKonstantin Sokolov
May 25, 2007·The Oncologist·Ruthann M GiustiRichard Pazdur
Apr 18, 2008·Anti-cancer Drugs·Muhammad Wasif SaifKostas N Syrigos
Nov 1, 2008·Cancer Research·Vincent T DeVita, Edward Chu
Dec 17, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·H MaedaJ Daruwalla
Dec 23, 2008·Chemical Reviews·Rakesh Kumar TekadeNarendra Kumar Jain
Apr 23, 2009·Molecular Oncology·Leonard Fass
May 12, 2009·International Journal of Pharmaceutics·Miao HeChunhua Yin
Jun 30, 2009·Angewandte Chemie·Alexander V Kabanov, Serguei V Vinogradov
Feb 9, 2010·Critical Reviews in Oncology/hematology·Roberto LabiancaJacques Wils
Feb 18, 2010·Chemical Communications : Chem Comm·Cristian SamorìAlberto Bianco
Jul 21, 2010·Nanoscale·Karla K CotíJ Fraser Stoddart

❮ Previous
Next ❯

Citations

Sep 3, 2021·European Journal of Pharmacology·Shadma WahabHashim Abbas

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.

Related Papers

Pharmaceutical Nanotechnology
Tianxu ZhangQiang Peng
Journal of Advanced Pharmaceutical Technology & Research
Nagina BelaliMuchtaridi Muchtaridi
Artificial Cells, Nanomedicine, and Biotechnology
Anekant Jain, Sanjay K Jain
© 2021 Meta ULC. All rights reserved