PMID: 9164377May 26, 1997Paper

Treating depressed primary care patients improves their physical, mental, and social functioning

Archives of Internal Medicine
J L CoulehanE Rodriguez

Abstract

This study describes the functioning of primary care patients with major depressive disorder, the relationship of medical comorbidity to functional status, and the effects of depression-specific treatment on functional status after 8 months. Patients were randomized to a protocol intervention (nortriptyline hydrochloride or interpersonal psychotherapy) or to usual care with the patient's physician in a clinical trial of primary care treatments of depression. Their functional status was evaluated using the Medical Outcomes Study 36-Item Short Form Health Survey (SF-36) and the Global Assessment Scale. Medical comorbidity was assessed with the Duke Severity of Illness Checklist. The Hamilton Rating Scale for Depression and Beck Depression Inventory were used to measure depressive severity. Assessments were conducted at baseline and at 1, 2, 4, and 8 months after randomization. At baseline, patients reported substantial impairments in the functional domains as assessed by the SF-36 and Global Assessment Scale. Severity of general medical illness and depression were not correlated. Greater medical comorbidity was associated with diminished physical, but not psychological, functioning. Mean scores on SF-36 scales and the Global Asse...Continue Reading

Citations

Aug 21, 2013·Primary Health Care Research & Development·Lena FlycktGunnar H Nilsson
Jan 22, 2003·Journal of General Internal Medicine·Susan C HedrickWayne Katon
Aug 2, 2006·Journal of General Internal Medicine·Margaret ShihTeresa J Brady
Sep 22, 1999·Journal of General Internal Medicine·L S GoldmanH C Champion
Feb 27, 2001·BMJ : British Medical Journal·V PatelA Reeler
Feb 27, 2008·Journal of General Internal Medicine·Gregory S CherrHasan H Dosluoglu
Apr 25, 2008·Psychosomatic Medicine·Glenn V OstirKenneth J Ottenbacher
Oct 7, 2004·Aging Clinical and Experimental Research·Patrizia MecocciUmberto Senin
Oct 16, 2002·Journal of Psychosomatic Research·Paolo Cassano, Maurizio Fava
Mar 15, 2011·Explore : the Journal of Science and Healing·Jeffrey S GellerG Dean Cleghorn
Mar 12, 2010·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Hyong Jin ChoMichael R Irwin
Aug 14, 2009·Patient Education and Counseling·Robert A BellRichard L Kravitz
Sep 25, 2007·General Hospital Psychiatry·Sara E MazzoniJoan Russo
Mar 4, 2005·Journal of the American Geriatrics Society·Christopher M CallahanUNKNOWN IMPACT Investigators
Oct 8, 2008·Bipolar Disorders·Gregory E SimonMark S Bauer
Dec 15, 2004·Journal of Psychosomatic Research·Paul A Kurdyak, William H Gnam
Sep 17, 2005·Biological Psychiatry·Sidney ZisookCarol B Rockett
Mar 7, 2006·The Spine Journal : Official Journal of the North American Spine Society·Michael A PahlTodd J Albert
Oct 4, 2005·Journal of Psychosomatic Research·Julie Jomeen, Colin R Martin
Aug 20, 2011·Archives of Physical Medicine and Rehabilitation·Adam T HirshMark P Jensen
Aug 2, 2003·Biological Psychiatry·Gregory E Simon
Jul 19, 2011·Journal of Clinical Epidemiology·Andreas SchröderPer Fink
Jan 22, 2013·General Hospital Psychiatry·Andrea N NilesMichelle G Craske
Mar 30, 2007·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Patrik SobockiBengt Jönsson
Dec 3, 1998·The Journal of Family Practice·M S Klinkman, I Okkes
Apr 20, 1999·International Journal of Psychiatry in Medicine·H C SchulbergC F Reynolds
Feb 19, 2003·Journal of Clinical Epidemiology·Samuel WiebeCasey Sidwell
Aug 6, 2016·Mayo Clinic Proceedings·Adil E BharuchaChristopher D Sletten

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.