Treating Diabetic Macular Oedema (DMO): real world UK clinical outcomes for the 0.19mg Fluocinolone Acetonide intravitreal implant (Iluvien™) at 2 years

BMC Ophthalmology
William Fusi-RubianoRupal Morjaria

Abstract

To compare visual function and structural improvements in pseudophakic eyes with diabetic macular oedema (DMO) treated with the 0.19mg Fluocinolone Acetonide (FAc) intravitreal implant (IluvienTM) in a 'real world' setting. A single centre retrospective evaluation of patients with DMO unresponsive to conventional treatment treated with the FAc implant according to UK guidelines. Primary efficacy endpoint was best corrected visual acuity (BCVA); secondary endpoints included optical coherence tomography evaluations of the macula (a) central retinal and (b) peak macular thickness collected at annual time points. Primary safety endpoint was new rise in IOP >27mmHg or glaucoma surgery. Patients with <1 year follow-up were excluded. Twenty-nine eyes were included, with mean(SD) follow up of 792(270) days. Improvement in BCVA and reduction in macular oedema was noted at all timepoints. Mean improvement in BCVA from baseline was 6 ETDRS letters at year 1(n=29), 6.5L at year 2(n=22) and 11L at year 3(n=6). Mean central retinal thickness at baseline was 451 microns, 337 microns at year 1, 342 microns at year 2 and 314 microns at year 3. Two eyes required IOP-lowering drops post implant. Supplementary treatment for persistence or recurren...Continue Reading

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Citations

Dec 18, 2018·The Journal of International Medical Research·Horace MassaGeorgios D Panos
Feb 21, 2019·Diabetes Technology & Therapeutics·Satish K Garg, Dominique Giordano
Apr 9, 2020·Current Medical Research and Opinion·Sarah E HoldenCraig J Currie
Jan 17, 2020·Taiwan Journal of Ophthalmology·Jorge Chawan-SaadLihteh Wu
Sep 20, 2018·Ophthalmology and Therapy·William Fusi-RubianoAlastair K Denniston
Aug 27, 2019·F1000Research·Riccardo SacconiFrancesco Bandello
Jan 10, 2021·Ophthalmology and Therapy·Alessandro ArrigoFrancesco Bandello
Jan 20, 2021·Indian Journal of Ophthalmology·Aditya SudhalkarAnand Sudhalkar
Feb 20, 2021·European Journal of Ophthalmology·Argyrios ChronopoulosLars-Olof Hattenbach
Mar 11, 2021·Journal of Ophthalmology·Claudio FurinoGiovanni Alessio

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