Abstract
The fundamental theory of traditional Chinese medicine (TCM) implies that when different diseases have the same pathogen, the syndromes of these individual diseases will be the same. "Treating different diseases with the same method" is a TCM principle suggesting that when different diseases have similar pathological changes during different stages of their development, the same method of treatment can be applied. Our study aims to analyze the concept "treating different diseases with the same method" from a molecular perspective, in order to clarify its biological basis and to objectively standardize future TCM syndrome research. The TCM syndromes Qi deficiency and blood stasis have similar pathogenesis in relation to coronary heart disease (CHD) and stroke. We aim to use big data technology and complex network theory to mine the genes specifically relevant to these TCM syndromes. This study aims to explore the correlation between the biological indicators of CHD and stroke from a scientific perspective. Mining the relevant neuroendocrine-immune (NEI) genes by means of gene entity recognition, complex network construction, network integration, and decomposition to categorize relevant syndrome terms and establish a digital dict...Continue Reading
References
Mar 1, 1987·Nature·J W Lichtman, P H Taghert
Jan 1, 1973·International Archives of Allergy and Applied Immunology·K Isaković, B D Janković
Mar 10, 2001·Bioinformatics·T OnoT Takagi
Jan 31, 2004·Bioinformatics·Minghua DengTing Chen
Aug 25, 2004·Science·Yael Artzy-RandrupLewi Stone
Jun 28, 2005·The European Journal of Neuroscience·Albrecht GüntherSteffen Rossner
May 23, 2006·Cell·Janghoo LimHuda Y Zoghbi
Jun 30, 2006·Biochemical and Biophysical Research Communications·Atsushi HosuiNorio Hayashi
Feb 3, 2007·Circulation Research·Mihail HristovChristian Weber
Mar 21, 2007·IET Systems Biology·S LiY Y Wang
Jul 16, 2008·BMC Bioinformatics·Zhong-Xi HuangKai-Tai Yao
Dec 31, 2008·Nature Reviews. Immunology·Jochen HuehnAlf Hamann
Mar 20, 2010·Molecular BioSystems·Tao MaShao Li
May 24, 2012·Stroke; a Journal of Cerebral Circulation·Adviye ErgulSusan C Fagan
Oct 10, 2013·QJM : Monthly Journal of the Association of Physicians·S S DingY Xu
Nov 12, 2014·Inflammation·Jörn F DopheideChristine Espinola-Klein
Mar 21, 2015·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Rui-Xing WangMo-Jun Lin
Mar 7, 2017·PloS One·Andre LamuriasFrancisco M Couto
Oct 27, 2018·Nucleic Acids Research·Hai-Yu XuLu-Qi Huang
Nov 1, 2018·Nucleic Acids Research·Yang WuJianxin Chen