Treating infants with neonatal abstinence syndrome: an examination of three protocols

Journal of Perinatology : Official Journal of the California Perinatal Association
Morgan J HartgroveCarla Saunders

Abstract

Describe the characteristics of infants with NAS and determine if treatment outcomes varied between three protocols. Based on medical record data, infant treatment for NAS-related withdrawal reflected one of three protocols: (1) No rescue dose (n = 836, 52.7%): Prescriber ordered initiation and escalation doses and determined when infants were eligible for weaning, (2) Rescue dose (n = 233, 14.7%): No rescue dose with the addition of a prescriber-ordered rescue dose, (3) Rescue dose by order set (n = 516, 32.6%): Rescue dose with addition of nurse-assisted order of morphine during escalation. The no rescue dose group had longer length of stay, days to wean, and inpatient days, and greater initial morphine dose than the two rescue dose groups (p < 0.001). Treatment outcomes between the two rescue dose protocols did not differ. The benefits related to rescue dosing further inform the development of a standardized NAS treatment protocol.

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Citations

Aug 6, 2020·Journal of Perinatology : Official Journal of the California Perinatal Association·Jifeng MaTimothy Boaz
Feb 21, 2021·Journal of Perinatology : Official Journal of the California Perinatal Association·Rachana SinghUNKNOWN for PNQIN Collaborative of Massachusetts
Mar 6, 2021·Seminars in Fetal & Neonatal Medicine·Rachana Singh, Jonathan M Davis
May 27, 2021·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Ankit RochaniGagan Kaushal

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