Treating migraine with contraceptives

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Gianni AllaisChiara Benedetto

Abstract

At least 18% of women suffers from migraine. Clinically, there are two main forms of migraine: migraine with aura (MA) and migraine without aura (MO) and more than 50% of MO is strongly correlated to the menstrual cycle. The high prevalence of migraine in females, its correlation with the menstrual cycle and with the use of combined hormonal contraceptives (CHCs) suggest that the estrogen drop is implicated in the pathogenesis of the attacks. Although CHCs may trigger or worsen migraine, their correct use may even prevent or reduce some forms of migraine, like estrogen withdrawal headache. Evidence suggested that stable estrogen levels have a positive effect, minimising or eliminating the estrogenic drop. Several contraceptive strategies may act in this way: extended-cycle CHCs, CHCs with shortened hormone-free interval (HFI), progestogen-only contraceptives, CHCs containing new generation estrogens and estrogen supplementation during the HFI.

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Citations

Mar 10, 2018·Climacteric : the Journal of the International Menopause Society·M A Hipolito RodriguesA Gompel
Jun 16, 2018·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Gianni AllaisChiara Benedetto
Jan 13, 2018·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Ilaria Di Donato, Antonio Federico
Oct 2, 2019·Current Opinion in Obstetrics & Gynecology·Amy J Voedisch, Nada Hindiyeh
Dec 8, 2017·Expert Opinion on Pharmacotherapy·G AllaisChiara Benedetto
Jun 2, 2018·Current Neurology and Neuroscience Reports·Candice ToddChristine Lay
Mar 16, 2021·Acta neurologica Belgica·Alanny Gabrielly Diógenes CampeloRaimundo Pereira Silva-Néto
Jun 10, 2021·Pain and Therapy·Marcello SilvestroAntonio Russo

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