Treating mild hypertension--an unnecessary luxury

Cardiovascular Drugs and Therapy
J R Hampton

Abstract

Clinical practice should be based on the results of good clinical trials, not on the opinion of individual doctors. This is particularly true of high blood pressure, for there is no disease of "hypertension," and only through clinical trials has the acceptable upper limit of blood pressure been identified. The large trials that have been performed, and in particular the MRC trial of bendrofluazide and propranolol, enable the benefits of treatment to be assessed and related to the incidence of unwanted effects of treatment. Many new drugs, which are usually very expensive, have not been subjected to large clinical trials and a "balance sheet" of their benefit and adverse effects cannot be drawn up. Drugs that have not been assessed in large trials must be regarded both as an unnecessary and an undesirable luxury.

References


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Citations

Feb 6, 2008·Metabolism: Clinical and Experimental·Michelangelo SartoriUNKNOWN HARVEST Group
Jun 8, 1991·Health Policy·M JohannessonL Råstam
Jul 18, 2002·Cardiology Clinics·Richard S Cooper, Ramon Durazo-Arvizu
Sep 14, 1991·BMJ : British Medical Journal
Aug 10, 1991·BMJ : British Medical Journal·R Burton
Jul 28, 2001·European Journal of Clinical Investigation·F TriposkiadisM Kyriakidis

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