Treating obstructive sleep apnea in adults with epilepsy: a randomized pilot trial.

Neurology
B A MalowY Song

Abstract

Small uncontrolled series suggest that treatment of obstructive sleep apnea (OSA) in patients with epilepsy may improve seizure control. Prior to conducting a definitive randomized controlled trial, we addressed critical design issues in a pilot study. We identified a cohort of adult patients with medically refractory epilepsy and coexisting OSA, documented by polysomnography (PSG). After an 8-week baseline period, subjects with OSA were randomized to therapeutic or sham continuous positive airway pressure (CPAP) for 10 weeks. Subjects maintained seizure calendars and antiepileptic drug dosages were held constant. Sixty-eight subjects with suspected OSA were enrolled and 35 subjects randomized to therapeutic CPAP (22 subjects) or sham (13 subjects) CPAP. Male gender and an elevated sleep apnea questionnaire score were predictive of OSA on PSG. Nineteen subjects in the therapeutic group and all 13 subjects in the sham group completed the trial. Baseline apnea-hypopnea index (AHI) and CPAP adherence were comparable between groups. A significant reduction in AHI was observed in the therapeutic CPAP group as compared to the sham group. Subjects, study coordinators, and principal investigators were unable to predict treatment alloca...Continue Reading

Associated Clinical Trials

Oct 8, 2002·Beth Ann Malow, Beth Ann Malow

Citations

Jun 16, 2009·Current Treatment Options in Neurology·Lynn Liu, J Craig Henry
Aug 7, 2012·Current Treatment Options in Neurology·Christopher Derry
Mar 15, 2011·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Madeleine Grigg-Damberger, Frank Ralls
Jun 14, 2012·Epilepsia·Athanasios GaitatzisJosemir W Sander
Jun 17, 2011·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·In-Soo LeeJoel E Dimsdale
Sep 8, 2011·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Fuzhan ParhizgarRishi Raj
May 3, 2013·Sleep & Breathing = Schlaf & Atmung·Martina VendrameSanford H Auerbach
Aug 27, 2014·Clinics in Chest Medicine·Maryann C Deak, Douglas B Kirsch
Sep 10, 2011·Sleep & Breathing = Schlaf & Atmung·Hala A ShaheenLamia M Afifi
Dec 3, 2014·Child and Adolescent Psychiatric Clinics of North America·Madeleine M Grigg-Damberger, Nancy Foldvary-Schaefer
Mar 10, 2011·Current Opinion in Neurology·Sofia H Eriksson
Mar 15, 2016·Sleep Medicine Clinics·Lynn Kataria, Bradley V Vaughn
Aug 15, 2014·Epilepsy & Behavior : E&B·Darakul PornsriniyomNancy Foldvary-Schaefer
Jun 22, 2014·Epilepsy & Behavior : E&B·S HolleyC M Hill
Jan 29, 2013·Sleep Medicine·Jose-Alberto PalmaJorge Iriarte
Oct 27, 2012·Neurologic Clinics·Marc Raphaelson, Sara K Inati
Oct 27, 2012·Neurologic Clinics·Bradley V Vaughn, Imran Ali
Oct 27, 2012·Neurologic Clinics·Alex Moszczynski, Brian James Murray
May 29, 2012·Pediatric Neurology·Eric SegalSanjeev V Kothare
Jul 26, 2011·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Devin L BrownLewis B Morgenstern
Mar 29, 2011·Sleep Medicine Reviews·Esther G A van GoldeAl W de Weerd
Feb 22, 2011·La Presse médicale·Philippe Derambure
Oct 19, 2010·Sleep Medicine Reviews·Lino NobiliCarlo A Tassinari
Jul 14, 2010·Journal of the Neurological Sciences·Gabriela MatosSergio Tufik
Jun 24, 2010·Epilepsy Research·Raffaele Manni, Michele Terzaghi
Mar 20, 2016·Epilepsy Research·Mark QuiggLee M Ritterband
Aug 11, 2015·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·C L BassettiT C Wetter
Jun 19, 2014·Seizure : the Journal of the British Epilepsy Association·Ellen J BubrickMilena K Pavlova
Mar 4, 2014·Epilepsy Research·Ryan G WagnerCharles R Newton
Jun 28, 2015·Sleep Medicine·S G KhachatryanM Manconi
Jun 15, 2015·Seminars in Pediatric Neurology·Sejal V Jain, Sanjeev V Kothare
Oct 30, 2012·Epilepsy & Behavior : E&B·Nancy Foldvary-SchaeferJames Bena
Mar 8, 2013·Epilepsy & Behavior : E&B·Christopher P Derry, Susan Duncan
Feb 12, 2011·Epilepsy & Behavior : E&B·S ChanJ H Cross
Jul 31, 2016·Sleep & Breathing = Schlaf & Atmung·Zhang LinZou Xiaoyi
Nov 22, 2016·Expert Review of Neurotherapeutics·Feng Liu, Xuefeng Wang
Dec 19, 2016·Neurophysiologie clinique = Clinical neurophysiology·Aude MauroussetNadège Limousin
May 15, 2012·Journal of Child Neurology·Sejal V JainTracy A Glauser
Jul 14, 2012·Journal of Child Neurology·Sejal V JainTracy A Glauser
Feb 3, 2018·Sleep·Shobi SivathambooTerence J O'Brien
Sep 1, 2018·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·S PopkirovC P Derry

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.