Treating opioid dependence with extended-release naltrexone (XR-NTX) in Ukraine: Feasibility and three-month outcomes.

Journal of Substance Abuse Treatment
Iuliia MakarenkoFrederick L Altice

Abstract

Although opioid agonist treatments (OAT) with methadone or buprenorphine are available to treat opioid use disorders (OUD) in Ukraine, OAT acceptability and coverage remains low. Extended-release naltrexone (XR-NTX) that recently became available as another treatment option provides new opportunities for treating OUDs in this region and we aimed to test its feasibility. Patients with OUD (N=135) and interested in treatment with XR-NTX were initiated on monthly XR-NTX injections and monitored for three months. Correlates of 3-month retention on XR-NTX and drug use at each time-point using self-reports and urine drug testing (UDT) were assessed. Of the 134 participants initiated XR-NTX, 101 (75%) completed three months, defined as 4 consecutive XR-NTX injections. Independent factors negatively associated with retention in XR-NTX treatment included previous maintenance with OAT (aOR=0.3; 95%CI=0.1-0.9) and extrinsic help-seeking treatment motivation (aOR=0.7; 95%CI=0.5-0.9). Of these 101 participants completing three months of treatment, opioid use markedly reduced using self-report (67%% to 22%; p>0.001) and UDT (77% to 24%; p<0.001) outcomes over time. Alcohol, marijuana and stimulant use, however, remained unchanged. Craving fo...Continue Reading

References

Jan 1, 1982·Addictive Behaviors·H A Skinner
Jan 1, 1980·The Journal of Nervous and Mental Disease·A T McLellanC P O'Brien
Aug 20, 2003·Journal of Psychoactive Drugs·Donald R Wesson, Walter Ling
Apr 7, 2005·JAMA : the Journal of the American Medical Association·James C GarbuttUNKNOWN Vivitrex Study Group
Apr 21, 2005·Annals of Epidemiology·Timothy Johnson, Michael Fendrich
Oct 15, 2005·Journal of Studies on Alcohol. Supplement·Bankole A JohnsonJohn D Roache
May 4, 2006·JAMA : the Journal of the American Medical Association·Raymond F AntonUNKNOWN COMBINE Study Research Group
Feb 20, 2007·Journal of Substance Abuse Treatment·Errol YudkoAdriana Fouts
Aug 10, 2007·Expert Opinion on Investigational Drugs·Sandra D ComerGary K Hulse
Sep 18, 2007·Journal of Clinical Psychopharmacology·Stephanie S O'MalleyHenry R Kranzler
Jan 2, 2009·Journal of Studies on Alcohol and Drugs·Celeste M CavinessMichael D Stein
Oct 7, 2011·The Cochrane Database of Systematic Reviews·Dawn StaceyRichard Thomson
Oct 6, 2012·Journal of Studies on Alcohol and Drugs·Mack C MitchellBernard L Silverman
Apr 5, 2013·Bulletin of the World Health Organization·Linda R GowingLouisa Degenhardt
Feb 7, 2014·The Cochrane Database of Systematic Reviews·Richard P MattickMarina Davoli
Mar 17, 2015·Substance Abuse : Official Publication of the Association for Medical Education and Research in Substance Abuse·Heide JacksonDavid J Vanness
Jan 29, 2016·Substance Abuse : Official Publication of the Association for Medical Education and Research in Substance Abuse·Hoa T VoMarc Fishman
Mar 31, 2016·The New England Journal of Medicine·Joshua D LeeCharles P O'Brien
Jun 28, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Andrea J LowPeter Vickerman
Jun 20, 2017·The International Journal on Drug Policy·Iuliia MakarenkoFrederick L Altice

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.