Treating Posttraumatic Stress Disorder Symptoms With Low Amplitude Seizure Therapy (LAP-ST) Compared With Standard Right Unilateral Electroconvulsive Therapy: A Pilot Double-Blinded Randomized Clinical Trial.

The Journal of ECT
Nagy A YoussefW Vaughn McCall

Abstract

An important barrier to further studying electroconvulsive therapy (ECT) in posttraumatic stress disorder (PTSD) is the cognitive adverse effects. However, recent data suggest that low amplitude seizure therapy (LAP-ST) has no or minimal cognitive adverse effects. The aims of this report were to examine the efficacy of LAP-ST in PTSD and to compare LAP-ST with standard right unilateral (RUL) ECT using a pilot randomized clinical trial. Patients were randomized to LAP-ST or RUL ECT. Posttraumatic stress disorder was assessed using clinical interview based on the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, and symptom severity with PTSD Checklist (PCL). The scores pertaining to PCL were analyzed using descriptive analysis for this pilot study. Eleven patients consented to be enrolled. Seven were randomly allocated to LAP-ST or RUL ECT. Five completed the study and had completed PCL before and after the course. In both groups, PTSD symptoms showed fast improvement. The effect size of improvement seems promising. The mean baseline PCL score for patients in the LAP-ST group was 42.5 (SD = 16.26) and the mean end point PCL score after treatment was 31 (SD = 15.56). The mean baseline PCL score for patients i...Continue Reading

Associated Clinical Trials

Oct 22, 2015·Nagy Adel Youssef

References

Jul 1, 1995·The American Journal of Psychiatry·C SobinM C McElhiney
Jan 28, 2003·Biological Psychiatry·Jonathan R T DavidsonSusan van Meter
Sep 28, 2004·CNS Spectrums·Mark B HamnerB Christopher Frueh
Jul 17, 2010·Brain Stimulation·Mushtaq A MargoobChittaranjan Andrade
Nov 26, 2015·Journal of Traumatic Stress·Christy A BlevinsJessica L Domino
Apr 21, 2016·Expert Review of Neurotherapeutics·Chittaranjan AndradeNagy A Youssef

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