Treating recurrent glioblastoma: an update

CNS Oncology
Carlos Kamiya-Matsuoka, Mark R Gilbert

Abstract

Glioblastoma, the most aggressive of the gliomas, has a high recurrence and mortality rate. The nature of this poor prognosis resides in the molecular heterogeneity and phenotypic features of this tumor. Despite research advances in understanding the molecular biology, it has been difficult to translate this knowledge into effective treatment. Nearly all will have tumor recurrence, yet to date very few therapies have established efficacy as salvage regimens. This challenge is further complicated by imaging confounders and to an even greater degree by the ever increasing molecular heterogeneity that is thought to be both sporadic and treatment-induced. The development of novel clinical trial designs to support the development and testing of novel treatment regimens and drug delivery strategies underscore the need for more precise techniques in imaging and better surrogate markers to help determine treatment response. This review summarizes recent approaches to treat patients with recurrent glioblastoma and considers future perspectives.

References

Nov 1, 1976·Archives of Neurology·C B WilsonK J Enot
Jul 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B JeremicL Mijatovic
Jun 1, 1987·Journal of Neurosurgery·P J KellyJ J Illig
Dec 1, 1996·American Journal of Clinical Oncology·M D PradosM Malec
Feb 25, 1999·Journal of Magnetic Resonance Imaging : JMRI·T SugaharaM Takahashi
Mar 18, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A A BrandesM V Fiorentino
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E T WongW K Yung
Nov 9, 2000·The New England Journal of Medicine·M EstellerJ G Herman
Jan 10, 2001·Neurology·A C KappelleJ J Heimans
Sep 11, 2001·Seminars in Oncology·D R Macdonald
Sep 20, 2001·Journal of the National Cancer Institute·K E WarrenF M Balis
Oct 28, 2003·European Journal of Nuclear Medicine and Molecular Imaging·Alexander BechererKurt Kletter
Mar 11, 2005·The New England Journal of Medicine·Roger StuppUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Nov 12, 2005·The New England Journal of Medicine·Ingo K MellinghoffPaul S Mischel
Nov 22, 2005·International Journal of Radiation Oncology, Biology, Physics·Yue CaoTheodore S Lawrence
Mar 1, 2006·Neurology·F SchmidtM Weller
Mar 10, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nicholas A ButowskiSusan M Chang
Jun 3, 2006·Cancer Research·Markus J RiemenschneiderDavid N Louis
Aug 11, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Arnab ChakravartiJay S Loeffler
Nov 23, 2006·Journal of Neuro-oncology·Zhang Xiangsong, Chen Weian
Jun 1, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christopher E PelloskiKenneth Aldape
Aug 1, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Antje WickWolfgang Wick
Oct 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·James J VredenburghHenry S Friedman
Jan 16, 2008·Expert Opinion on Biological Therapy·Cory AllenEvanthia Galanis
May 1, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alba A BrandesMario Ermani
Jul 29, 2008·Journal of Neuro-oncology·Camilo E FadulJ Marc Pipas
Sep 6, 2008·Nature·UNKNOWN Cancer Genome Atlas Research Network
Nov 20, 2008·Journal of Neuro-oncology·Maria Grazia FabriniLuca Cionini
Dec 31, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Teri N KreislHoward A Fine

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Citations

Mar 5, 2016·Acta Biochimica Et Biophysica Sinica·Jin ZhengHuilin Gong
Jul 17, 2015·Neurosurgery·Michelle E De Witt, John A Boockvar
Feb 1, 2017·Seminars in Immunopathology·David A Reardon, Duane A Mitchell
Jun 13, 2017·Neuro-oncology·Jing WuC Ryan Miller
May 20, 2018·Cancer Medicine·Rui LiuQi Wan
Aug 14, 2020·Journal of Neuropathology and Experimental Neurology·Stine Asferg PettersonBjarne Winther Kristensen
Sep 3, 2016·Journal of Hematology & Oncology·Haouraa MostafaE Marion Schneider
Mar 8, 2019·Nature Medicine·Hirotaka ItoE Antonio Chiocca
Nov 10, 2015·Oncology Reports·Igor BryukhovetskiyPolina Mischenko
Aug 16, 2019·Science Translational Medicine·E Antonio ChioccaLaurence J N Cooper
Jul 1, 2020·Journal of Neuro-oncology·Na Tosha N GatsonVinay K Puduvalli
Aug 16, 2015·Integrative Cancer Therapies·Gregory T LevinRobert U Newton
Oct 19, 2019·World Neurosurgery·Joshua E SimonEdward Melian
Aug 7, 2021·NPJ Precision Oncology·Aaron S MansfieldRahul Aggarwal
Mar 18, 2019·Biochemical Pharmacology·Rosângela Mayer GonçalvesAlfeu Zanotto-Filho
Nov 2, 2021·Frontiers in Molecular Biosciences·Zhenyuan HanZhen Tian

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Methods Mentioned

BETA
imaging techniques
biopsy

Clinical Trials Mentioned

NCT01730950
NCT01290939
NCT00777153
NCT01434602
NCT01498328
NCT02017717
NCT00916409
NCT01113398
NCT01290263
NCT01609790

Software Mentioned

RESCUE

Related Concepts

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