Treatment adherence and transitioning youth in pediatric multiple sclerosis

Multiple Sclerosis and Related Disorders
Sabeen LuluEmmanuelle Waubant

Abstract

Transitioning youth with multiple sclerosis (MS) represent a vulnerable group to potentially poor outcomes. It is unknown how pediatric MS patients transition into adult care. To describe self-management skills that include adherence to disease-modifying therapies, quality of life measures, illness perception, transition readiness and healthcare skills assessments in patients with pediatric MS and associations with clinical and cognitive outcomes. This is a prospective cross-sectional study at the pediatric MS center and transitional MS clinic at the University of California, San Francisco. Patients and one of their parents completed validated surveys for self-management skills. Non-adherence is defined as not taking their medication more than 20% of the time in the past 1 month. Wilcoxin matched-pairs rank test and McNemar's tests were used for comparison of patient and parent responses. Univariate and multivariate regression models were used for analyses adjusting for disease duration and socio-economic status. Thirty patients were enrolled with a mean (+/-SD) age of 15.8 years+/-2.8, 53% was female and 47% Hispanic. The rate of non-adherence was 37%. The most common reason for non-adherence was forgetting to take their medic...Continue Reading

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Citations

Oct 27, 2015·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·J Nicholas Brenton, Brenda L Banwell
Jul 31, 2016·Multiple Sclerosis : Clinical and Laboratory Research·Carla FranciscoEmmanuelle Waubant
Sep 13, 2017·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Marisa McGinley, Ian T Rossman
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Apr 2, 2019·Developmental Medicine and Child Neurology·Sophie DuignanYael Hacohen
Jul 8, 2020·Multiple Sclerosis : Clinical and Laboratory Research·Yael HacohenOlga Ciccarelli
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Sep 29, 2019·Current Treatment Options in Neurology·Gabrielle MacaronMary Rensel
Mar 10, 2017·Multiple Sclerosis : Clinical and Laboratory Research·Carolyn E SchwartzE Ann Yeh
Mar 23, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Giovanna Borriello, Carlo Pozzilli
Mar 27, 2021·Developmental Medicine and Child Neurology·Nikki OwNancy E Mayo
May 23, 2021·Neurology. Neuroimmunology and Neuroinflammation·Omar A Abdel-MannanUNKNOWN UK-Childhood Inflammatory Disease Network
Aug 28, 2021·International Journal of Environmental Research and Public Health·Slávka MroskováĽubomíra Tkáčová

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