Treatment Algorithms for Systemic Sclerosis According to Experts

Arthritis & Rheumatology
Andreu Fernández-CodinaScleroderma Algorithm Group

Abstract

There is a lack of agreement regarding treatment for many aspects of systemic sclerosis (SSc). We undertook this study to generate SSc treatment algorithms endorsed by a high percentage of SSc experts. Experts from the Scleroderma Clinical Trials Consortium and the Canadian Scleroderma Research group (n = 170) were asked whether they agreed with SSc algorithms from 2012. Two consensus rounds refined agreement; 62, 54, and 48 experts (36%, 32%, and 28%, respectively) completed the first, second, and third surveys, respectively. For treatment of scleroderma renal crisis, 81% of experts agreed (first-, second-, and third-line treatments were angiotensin-converting enzyme inhibitors, then adding calcium-channel blockers [CCBs], then adding angiotensin receptor blockers [ARBs], respectively). For pulmonary arterial hypertension (PAH), 81% of experts agreed (for mild PAH, treatments were phosphodiesterase 5 [PDE5] inhibitors, then endothelin receptor antagonists plus PDE5 inhibitors, then prostanoids, respectively; for severe PAH, prostanoids were first-line treatment). For mild Raynaud's phenomenon (RP), 79% of experts agreed (treatments were CCBs, then adding PDE5 inhibitors, then ARBs or switching to another CCB, respectively; aft...Continue Reading

Associated Clinical Trials

Aug 1, 2018·Andreu Fernandez Codina

References

Feb 8, 2006·Arthritis and Rheumatism·Janet E PopeAdriana Krizova
Mar 3, 2007·Annals of the Rheumatic Diseases·Virginia D Steen, Thomas A Medsger
Apr 3, 2012·Seminars in Arthritis and Rheumatism·Kyle M WalkerUNKNOWN Canadian Scleroderma Research Group (CSRG)
Dec 21, 2012·Annals of the Rheumatic Diseases·Muriel ElhaiUNKNOWN EUSTAR (EULAR Scleroderma Trials and Research group)
Apr 5, 2013·Arthritis Care & Research·Theresa TingeyJanet Pope
Dec 15, 2015·Drugs·Jason J Lee, Janet E Pope
May 6, 2016·Current Rheumatology Reports·Jessica K Gordon, Robyn T Domsic
May 11, 2016·JAMA : the Journal of the American Medical Association·Dinesh KhannaUNKNOWN DUAL-2 Investigators
Jan 1, 2015·Nature Reviews. Disease Primers·Yannick AllanoreJohn Varga
Jun 11, 2016·Rheumatology·Christopher P DentonUNKNOWN BSR and BHPR Standards, Guidelines and Audit Working Group
Dec 13, 2016·Annals of the Rheumatic Diseases·Otylia Kowal-BieleckaUNKNOWN EUSTAR Coauthors
Dec 29, 2016·Arthritis & Rheumatology·Yanjie HaoUNKNOWN Australian Scleroderma Interest Group
Jan 16, 2017·Seminars in Arthritis and Rheumatism·Russell Edward Pellar, Janet Elizabeth Pope
Jan 28, 2017·British Dental Journal·A CurtoJ Sanchez
Feb 12, 2017·Annals of the Rheumatic Diseases·Ariane L HerrickChristopher P Denton
Apr 8, 2017·Current Rheumatology Reports·Rupal J Shah, Francesco Boin
Apr 18, 2017·Lancet·Christopher P Denton, Dinesh Khanna
Aug 25, 2017·Annals of the Rheumatic Diseases·Muriel ElhaiUNKNOWN EUSTAR group
Jan 4, 2018·The New England Journal of Medicine·Keith M SullivanUNKNOWN SCOT Study Investigators

❮ Previous
Next ❯

Citations

Feb 24, 2019·Nature Reviews. Rheumatology·Elizabeth R Volkmann, John Varga
Apr 11, 2019·Annals of the Rheumatic Diseases·Muriel ElhaiUNKNOWN for EUSTAR network
Jul 23, 2019·Current Medical Research and Opinion·Marlies WijsenbeekVincent Cottin
Nov 22, 2019·Modern Rheumatology·Masataka Kuwana, Arata Azuma
Aug 20, 2019·Clinical Rheumatology·John D PaulingJanet E Pope
Mar 18, 2020·Expert Opinion on Investigational Drugs·Melody P Chung, Lorinda Chung
Mar 25, 2020·Current Opinion in Rheumatology·David Roofeh, Dinesh Khanna
Mar 15, 2019·Current Opinion in Rheumatology·David RoofehDinesh Khanna
Mar 15, 2019·Current Opinion in Rheumatology·Vivek Nagaraja
Feb 23, 2020·The European Respiratory Journal·Oliver DistlerToby M Maher
Oct 16, 2019·The Australasian Journal of Dermatology·Christopher Y ChewAmanda M Saracino
Jun 9, 2020·Expert Review of Clinical Immunology·Yoshioki Yamasaki, Masataka Kuwana
Jul 18, 2020·Expert Opinion on Pharmacotherapy·Zsuzsanna H McMahan, Elizabeth R Volkmann
Jun 21, 2020·Arthritis & Rheumatology·Robert W Simms
May 16, 2019·Zeitschrift für Rheumatologie·M O BeckerB Maurer
Aug 20, 2019·Clinical Rheumatology·Aryeh Fischer, Jörg Distler
Jan 22, 2020·Rheumatology International·Durga Prasanna MisraVikas Agarwal
Sep 11, 2020·Current Cardiology Reports·Apostolos KontziasQingPing Yao
Jul 16, 2019·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Alan Tyndall
Oct 1, 2019·Expert Review of Clinical Immunology·Oliver DistlerToby M Maher
May 24, 2019·Advances in Therapy·Toby M Maher, Wim Wuyts
Jan 31, 2020·Respiratory Research·Alyson W WongSabina A Guler
Aug 7, 2019·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·M O BeckerB Maurer
Jul 11, 2020·Journal of Hypertension·Philippe GosseAntoine Cremer
Oct 4, 2020·Expert Review of Clinical Pharmacology·Bénédict Fallet, Ulrich A Walker
Nov 26, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Chiara SistFrancesco Teatini
Jan 16, 2021·Clinical Reviews in Allergy & Immunology·Ming ZhaoQianjin Lu
Dec 19, 2020·Autoimmunity Reviews·Carla VarricaSandra Simões
Nov 17, 2020·Frontiers in Immunology·Francesca MottaCarlo Selmi
Feb 19, 2021·Orphanet Journal of Rare Diseases·Alessio CoiAnna Pierini
Mar 7, 2021·Pharmaceuticals·Barbara RuaroCosimo Bruni
Feb 7, 2021·La Presse médicale·Marie HudsonVirginia Steen
Mar 23, 2021·Best Practice & Research. Clinical Rheumatology·Martin Aringer, Gabriela Riemekasten
Apr 4, 2021·Pharmaceuticals·Eun Ha Kang, Yeong Wook Song

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.