Treatment and Outcome in 65 Children with Optic Pathway Gliomas

World Neurosurgery
Mohamed A El BeltagyNada El-Khateeb

Abstract

Optic pathway gliomas (OPGs) are rare neoplasms in children with an unpredictable clinical course. There is significant controversy regarding the optimal management and outcome of these patients. Charts of all patients with OPG diagnosed and treated at Children's Cancer Hospital Egypt between July 2007 and July 2014 were retrospectively reviewed. We evaluated the roles of surgical, ophthalmologic, endocrinologic, neurologic, and treatment aspects of care. Sixty-five patients were included in this study, with a mean age of 5.3 years. OPGs were chiasmatic (n = 25), optic nerve (n = 18), hypothalamic (n = 7), and chiasmatic/hypothalamic (n = 7). Extensive involvement of the optic pathway was seen in an additional 8 patients. Twenty cases had neurofibromatosis type 1. Four cases underwent surgical debulking, and 28 were biopsied (16 open, 11 stereotactic, and 1 endoscopic). Nine of the 18 optic nerve tumors were managed by total excision. Twenty-four patients did not undergo any surgical intervention. Forty-five patients received chemotherapy. Histopathology revealed pilocytic (n = 20), pilomyxoid (n = 15), fibrillary astrocytoma (n = 4), and grade I papillary-glioneuronal tumor (n = 1). Nonrepresentative sample (n = 1). The 4-year...Continue Reading

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Citations

Feb 10, 2018·Journal of Neurosurgery·Kirsten van BaarsenShlomi Constantini
Oct 20, 2018·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Sarah Bin AbdulqaderAbdulrazag Ajlan
Jul 22, 2020·Journal of Child Neurology·Débora SallesJoão Norberto Stávale
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Nov 18, 2021·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Mohamed Reda RadyMohamed A El Beltagy

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