Treatment and outcome of pulmonary arterial hypertension in HIV-infected patients: a review of the literature

Current HIV Research
Stefania CicaliniN Petrosillo

Abstract

Pulmonary arterial hypertension (PAH) is a life-threatening complication of HIV infection. The prevalence of HIV-associated PAH (HIV-PAH) seems not to be changed over time, regardless of the introduction of highly active antiretroviral therapy (HAART). HIV-PAH treatment is similar to that for all PAH conditions and includes lifestyle modifications, general treatments, and disease-specific treatments. We reviewed the cases of HIV-PAH reported in the Literature in order to evaluate the role of HAART and specific PAH therapy in the prognosis and outcome of HIV-PAH. The research was performed through the PubMed database, by using the following key words: human immunodeficiency virus, AIDS, pulmonary hypertension, antiretroviral, and treatment. The outcome was reported as survival at the end of the observation period of each study. We found 509 patients with HIV-PAH described in the literature to date. At the end of follow-up period, survival rates were 55% and 22% among patients treated or not with antiretroviral therapy (ART), respectively (p = 0.02). Moreover, survival rates at the end of follow-up were 76% and 32% among patients treated or not with specific therapy for PAH (PAH-ST), respectively (p<0.0000001). Survival rates wer...Continue Reading

Citations

Apr 23, 2011·Expert Review of Respiratory Medicine·Stefania CicaliniNicola Petrosillo
Jul 6, 2014·The American Journal of the Medical Sciences·Bashar Staitieh, David M Guidot
Feb 13, 2016·Expert Review of Clinical Pharmacology·Pierangelo Chinello, Nicola Petrosillo
Nov 12, 2015·Current Opinion in Infectious Diseases·Paul Collini, Alison Morris
Jun 16, 2010·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·S CicaliniS Flores
Jan 5, 2013·La Revue de médecine interne·L FardetJ Capeau
Jun 5, 2012·Enfermedades infecciosas y microbiología clínica·M A Eulalia Valencia Ortega
Dec 15, 2018·Current Medical Research and Opinion·Michael McGeeNicholas Collins
Apr 16, 2018·Archivos de cardiología de México·José Luis Sandoval Gutiérrez
Nov 26, 2011·Expert Review of Clinical Pharmacology·Julie John, Harold Palevsky

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