Treatment and outcomes of recurrent hepatocellular carcinomas

Langenbeck's Archives of Surgery
Gaëtan-Romain JoliatNermin Halkic

Abstract

Surgery is one of the best options for curative treatment of hepatocellular carcinomas (HCC). Recurrences are nevertheless common (45-75%). This study aimed to compare overall survival (OS) of patients with recurrent HCC after primary resection to OS of patients without recurrence. A retrospective review of all HCC patients operated between 1993 and 2015 was performed. Median and 5-year OS were calculated. This study included 147 HCC patients. Sixty-seven patients presented a recurrence (46%). Patients with recurrence had a worse prognosis than those without recurrence (median OS 63 vs. 82 months, 5-year OS 47 vs. 54%, p = 0.036). First-line performed treatments were radiofrequency ablation (18, RFA), chemo-embolization (16, TACE), repeat hepatectomy (10), systemic chemotherapy (4), radio-embolization (1), and alcoholization (1). Palliative care was performed in 17 patients. Median OS of patients treated by RFA, TACE, or repeat hepatectomy were similar (77, 71, and 84 months, p = 0.735). Patients treated with chemotherapy/palliative care had lower median OS compared to interventional treatments (20 vs. 77 months, p < 0.0001). Recurrence after surgical HCC resection is frequent and negatively impacts OS. Interventional treatment...Continue Reading

References

Dec 1, 1982·American Journal of Clinical Oncology·M M OkenP P Carbone
Jan 24, 2006·Journal of the American College of Surgeons·Shimul A ShahCharles M Vollmer
Jun 23, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Vincenzo MazzaferroLuigi Mariani
Oct 14, 2011·The New England Journal of Medicine·Hashem B El-Serag
Apr 26, 2014·World Journal of Gastroenterology : WJG·Ali Raza, Gagan K Sood
Jul 1, 2014·Annals of Transplantation : Quarterly of the Polish Transplantation Society·Yi-Chiao ChengChung-Bao Hsieh
Jul 11, 2014·Annals of Surgery·Parissa TabrizianSasan Roayaie
Sep 5, 2014·Annals of Surgery·Yoshihiro MiseNorihiro Kokudo
Dec 2, 2014·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·K WangF Shen
Mar 17, 2015·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Yo-Ichi YamashitaYoshihiko Maehara
May 10, 2015·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Shin HwangSung-Gyu Lee
May 23, 2015·AJR. American Journal of Roentgenology·Qing-Quan ZuHai-Bin Shi
Jul 15, 2015·World Journal of Hepatology·Laurence Lacaze, Michel Scotté
Dec 15, 2015·Journal of Surgical Oncology·Kelly LafaroTimothy M Pawlik
Jan 5, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Angelo Sangiovanni, Massimo Colombo
Jan 19, 2016·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Peng S KohChung M Lo
Aug 29, 2016·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Mahmoud Abdelwahab AliChao-Long Chen

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Citations

Jan 6, 2018·Surgical Innovation·Eva LietoAnnamaria Auricchio
Mar 15, 2018·European Journal of Gastroenterology & Hepatology·Gaëtan-Romain JoliatNermin Halkic
Apr 30, 2020·Journal of Cellular Biochemistry·Fulei LiZujiang Yu
Dec 10, 2019·Molecular and Clinical Oncology·Motohiro MurakamiHideyuki Sakurai
Feb 13, 2020·Journal of Translational Medicine·Zheng WangLixian Ma
Jun 4, 2021·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Yao YangQiang Zhu
Oct 23, 2021·Frontiers in Cell and Developmental Biology·Ze-Bing SongShao-Qiang Li

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