Treatment and prevention of bone complications from prostate cancer.

Bone
Richard J LeeMatthew R Smith

Abstract

Bone metastases and skeletal complications are major causes of morbidity in prostate cancer patients. Despite the osteoblastic appearance of bone metastases on imaging studies, patients have elevated serum and urinary markers of bone resorption, indicative of high osteoclast activity. Increased osteoclast activity is independently associated with higher risk of subsequent skeletal complications, disease progression, and death. Osteoclast-targeted therapies are therefore a rational approach to reduction of risk for disease-related skeletal complications, bone metastases, and treatment-related fractures. This review focuses on recent advances in osteoclast-targeted therapy in prostate cancer. Bisphosphonates have been extensively studied in men with prostate cancer. Zoledronic acid significantly decreased the risk of skeletal complications in men with castration-resistant prostate cancer and bone metastases, and it is FDA-approved for this indication. Denosumab is a human monoclonal antibody that binds and inactivates RANKL, a critical mediator of osteoclast differentiation, activation, and survival. Recent global phase 3 clinic trials demonstrated an emerging role for denosumab in the treatment of prostate cancer bone metastases...Continue Reading

References

Jul 1, 1991·British Journal of Urology·N W ClarkeN J George
Nov 15, 1997·Cancer·M J RogersR G Russell
Jan 1, 1997·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·B GullbergJ A Kanis
Aug 6, 1998·The New England Journal of Medicine·I J DielG Bastert
Feb 7, 2001·The Journal of Clinical Endocrinology and Metabolism·B Z LederJ S Finkelstein
Sep 29, 2001·The New England Journal of Medicine·M R SmithJ S Finkelstein
Aug 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Trevor PowlesLiisa Pylkkänen
Oct 3, 2002·Journal of the National Cancer Institute·Fred SaadUNKNOWN Zoledronic Acid Prostate Cancer Study Group
Aug 30, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D S ErnstW Parulekar
Sep 4, 2003·Journal of the National Cancer Institute·David P DearnaleyUNKNOWN Mrc Pr05 Collaborators
Oct 29, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eric J SmallMildred Ortu Kowalski
Apr 16, 2004·The New England Journal of Medicine·G David Roodman
Jun 3, 2004·Journal of the National Cancer Institute·Fred SaadUNKNOWN Zoledronic Acid Prostate Cancer Study Group
Jun 5, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Pirow J BekkerAlex M DePaoli
Jul 9, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Toru HiragaToshiyuki Yoneda
Aug 5, 2004·The Journal of Clinical Endocrinology and Metabolism·Matthew R SmithJoel S Finkelstein
Oct 8, 2004·The New England Journal of Medicine·Ian F TannockUNKNOWN TAX 327 Investigators
Oct 8, 2004·The New England Journal of Medicine·Daniel P PetrylakE David Crawford
Oct 13, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Nancy MorabitoNicola Frisina
Jan 6, 2005·Journal of the National Cancer Institute·Janet E BrownRobert E Coleman
Jan 14, 2005·The New England Journal of Medicine·Vahakn B ShahinianJames S Goodwin
Apr 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Matthew R SmithCelestia S Higano
Feb 21, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jean-Jacques BodyPirow J Bekker
Jun 3, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Richard J CookMatthew R Smith
Jun 15, 2006·International Journal of Urology : Official Journal of the Japanese Urological Association·Hideki AsahiMikio Namiki
Oct 26, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michael A Carducci, Antonio Jimeno
Jan 4, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Matthew R Smith
Mar 21, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M Dror MichaelsonMatthew R Smith
May 17, 2007·Journal of the National Cancer Institute·Malcolm D MasonUNKNOWN Medical Research Council PR04 Collaborators
Jul 20, 2007·Arthritis Research & Therapy·Brendan F Boyce, Lianping Xing
Jul 20, 2007·Arthritis Research & Therapy·Edward M Schwarz, Christopher T Ritchlin
Sep 6, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Allan LiptonSusie Jun
Mar 17, 2009·The Journal of Urology·Philip J Saylor, Matthew R Smith
May 29, 2009·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Aug 13, 2009·The New England Journal of Medicine·Matthew R SmithUNKNOWN Denosumab HALT Prostate Cancer Study Group
Aug 21, 2010·The Journal of Urology·Matthew R SmithMitchell S Steiner

❮ Previous
Next ❯

Citations

Aug 10, 2012·Wiener medizinische Wochenschrift·Stefan Kudlacek, Thomas Puntus
Nov 5, 2013·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·P Mongiat-ArtusC Bastide
May 23, 2012·Oncogene·M K HerroonI Podgorski
Aug 7, 2013·Prostate Cancer and Prostatic Diseases·P CormieD A Galvão
Sep 14, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Mohd Azri Abd JalilNorliza Muhammad
Sep 15, 2012·Clinical Interventions in Aging·Andrew J Yee, Noopur S Raje
Jun 30, 2012·Therapeutics and Clinical Risk Management·Loredana Cavalli, Maria Luisa Brandi
Mar 2, 2013·Radiology·Joseph E BurnsRonald M Summers
Nov 19, 2013·Clinical & Experimental Metastasis·Sandy R LarsonColm Morrissey
Jan 17, 2014·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Benjamin A SpencerAlfred I Neugut
Jul 31, 2013·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·David A GerardDavid O Pickett
Oct 23, 2012·The Urologic Clinics of North America·Alicia K Morgans, Matthew R Smith
Oct 22, 2011·Urologic Oncology·Eric A Singer, Ramaprasad Srinivasan
May 3, 2011·Biomaterials·Marco A Lopez-HerediaX Frank Walboomers
Mar 11, 2011·Mayo Clinic Proceedings·Caroline J Davidge Pitts, Ann E Kearns
Aug 25, 2015·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Cynthia Campbell-BairdArun Balakumaran
Aug 23, 2011·CA: a Cancer Journal for Clinicians·Mark A LewisTimothy J Moynihan
May 12, 2011·Transplant International : Official Journal of the European Society for Organ Transplantation·Anke Heidewig HautmannErnst Holler
Mar 3, 2011·International Journal of Cancer. Journal International Du Cancer·Jung-Kang JinGary E Gallick
Sep 23, 2014·Expert Opinion on Pharmacotherapy·Stavros SfoungaristosPetros Perimenis
Apr 17, 2016·Tissue Engineering. Part a·Kambiz FarbodSander C G Leeuwenburgh
Mar 6, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Andreas ThorstensonJan Adolfsson
Mar 25, 2015·Clinical & Experimental Metastasis·Aimalie L HardawayIzabela Podgorski
Oct 2, 2012·Clinical Journal of Oncology Nursing·Heather Millar, Joyce Davison
Oct 17, 2017·Medicine and Science in Sports and Exercise·Daniel A GalvãoRobert U Newton
Mar 24, 2018·The Prostate·Christian CamposAlejandro S Godoy
Nov 25, 2017·Experimental & Molecular Medicine·Mei-Hsiu LiaoRuei-Ming Chen
Dec 14, 2018·Cancer Biotherapy & Radiopharmaceuticals·Zhi-Yuan ZhuDa-Peng Li
Jul 24, 2013·Briefings in Functional Genomics·Bryan D HudsonGabriela G Loots
Sep 25, 2020·Social Work in Public Health·Ameneh JafariZahra Jafari
Nov 6, 2015·Current Pharmacology Reports·Suleman S HussainAddanki P Kumar
Apr 5, 2020·Scientific Reports·Robin A NadarSander C G Leeuwenburgh
Feb 24, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Khalid A MohamedaliNora M Navone
Jan 17, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Daniel E HagamanMarites P Melancon

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Related Papers

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Philip J SaylorMatthew R Smith
Prostate Cancer and Prostatic Diseases
Philip J Saylor, Matthew R Smith
© 2021 Meta ULC. All rights reserved