Treatment and prevention of necrotizing enterocolitis

Seminars in Neonatology : SN
Jane S Lee, Richard A Polin

Abstract

Necrotizing enterocolitis (NEC) is the most common serious, acquired gastrointestinal disorder in the newborn infant. Although many variables are associated with development of NEC, only prematurity has been consistently identified in case-controlled studies. Traditionally, the diving seal reflex has been invoked as the mechanism responsible for ischaemic injury and necrosis. Intestinal ischaemia is likely to be the final common pathway in NEC; however, it is due to the release of vasoconstricting substances, such as platelet activating factor, rather than perinatal asphyxia. Bacteria and/or bacterial toxins are likely to have a key role in the pathogenesis of NEC by fostering production of inflammatory mediators. The role of feeding practices in the pathogenesis of NEC remains controversial. Treatment of infants with NEC generally includes a regimen of bowel rest, gastric decompression, systemic antibiotics and parenteral nutrition. Infants with perforation are generally operated upon; however, there has been recent interest in primary peritoneal drainage as an alternative. Prevention of NEC still remains elusive. Avoidance of preterm birth, use of antenatal steroids and breast-milk feeding are practices that offer the greates...Continue Reading

References

Mar 21, 2009·Pediatric Surgery International·Mikael PetrosyanHenri R Ford
Oct 16, 2012·Neuropsychology Review·Carly MolloyPeter J Anderson
Aug 3, 2012·The British Journal of Nutrition·Lyvonne TumeLynne Latten
Oct 19, 2013·Nutrition Research Reviews·Sonja N HeinritzEva Weiss
Apr 16, 2011·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Amir Ben TovRonit Lubetzky
Mar 5, 2013·Surgical Infections·Ryan K NelsonJohn A Alverdy
Jul 22, 2008·Nursing Research·Katherine E Gregory
Jul 7, 2011·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·Katherine E GregoryLinda J Van Marter
Oct 18, 2011·Journal of Pediatric Gastroenterology and Nutrition·Juli M RichterPeter J Giannone
Aug 30, 2012·Pediatric Emergency Care·George SakellarisChristina Giannakopoulou
Apr 23, 2005·Archives of Disease in Childhood. Fetal and Neonatal Edition·N Marlow, H Budge
Apr 23, 2005·Archives of Disease in Childhood. Fetal and Neonatal Edition·S S Premji
May 26, 2011·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Julia B EwaschukCatherine J Field
Nov 10, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Kriston GanguliN N Nanthakumar
Jun 29, 2007·Pediatric Research·Rob M J MoonenEduardo Villamor
Oct 7, 2010·Pediatric Research·Malene S CilieborgPer T Sangild
Nov 22, 2005·International Journal of Hematology·Stanislaw HaćZbigniew Sledziński
Apr 15, 2008·World Journal of Gastroenterology : WJG·Kareena-L SchnablMichael-T Clandinin
Sep 22, 2012·ISRN Gastroenterology·Bhoomika K Patel, Jigna S Shah
Mar 22, 2007·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Monica EpelmanJ Ted Gerstle
Jun 11, 2005·American Journal of Infection Control·Michael T Brady
Mar 30, 2007·Digestive Diseases and Sciences·Dan TurnerMichael S Schimmel
Jul 3, 2010·Fetal and Pediatric Pathology·Robert D ChristensenGail E Besner
Dec 3, 2009·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Francesca GotschLami Yeo
Mar 20, 2015·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Amy WilcockSuresh Victor
Dec 6, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Mohamed Abdelmaaboud, Abdelbaset Mohammed
Mar 1, 2016·Frontiers in Cellular and Infection Microbiology·Thilini N JayasingheJustin M O'Sullivan
Dec 19, 2013·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Jixin YangGail E Besner
Apr 25, 2013·Seminars in Pediatric Surgery·Daniel Watkins, Gail E Besner
Jun 28, 2007·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·Brigit M Carter
Jan 31, 2012·Early Human Development·Malene S CilieborgPer T Sangild
Nov 15, 2011·Journal of Pediatric Surgery·Ahmet GuvenAhmet Korkmaz
Nov 15, 2011·Journal of Pediatric Surgery·Cumhur AydemirUgur Dilmen
Apr 15, 2011·The Journal of Pediatrics·Vanaja N AlexanderMatthew J Bizzarro
Jan 5, 2011·The Journal of Nutritional Biochemistry·Richard H SiggersPer T Sangild

Citations

Nov 24, 1978·JAMA : the Journal of the American Medical Association·E G Brown, A Y Sweet
Sep 1, 1979·The Journal of Pediatrics·R M KliegmanA A Fanaroff
Apr 29, 1978·British Medical Journal·C D Lund
Dec 22, 1990·Lancet·A Lucas, T J Cole
Jul 1, 1990·The Journal of Pediatrics·R M Kliegman
Jul 1, 1990·The Journal of Pediatrics·D W Scheifele
Oct 1, 1990·Journal of Pediatric Gastroenterology and Nutrition·V Carrion, E A Egan
Oct 1, 1989·American Journal of Perinatology·R F CovertP A Gimotty
Jul 7, 1988·The New England Journal of Medicine·M M EiblA Rosenkranz
Jun 1, 1988·Journal of Pediatric Surgery·H W CheuD A Lloyd
Apr 26, 1984·The New England Journal of Medicine·R M Kliegman, A A Fanaroff
Jul 1, 1995·Scandinavian Journal of Gastroenterology·J G Ruseler-van EmbdenP Marteau
Jun 1, 1995·Journal of Paediatrics and Child Health·R TobianskyM Veddovi
Aug 1, 1995·Diseases of the Colon and Rectum·A KabeerC Coren
Aug 1, 1994·Journal of Pediatric Surgery·M I RoweP J Healey
Jun 1, 1994·Current Opinion in Pediatrics·J M Van CampA G Coran
Jan 1, 1994·Acta Paediatrica. Supplement·A M Kosloske
Feb 1, 1994·Journal of Pediatric Surgery·L J MorganG E Hartman
Aug 1, 1993·Journal of Pediatric Surgery·M D StringerL Spitz
Jan 1, 1993·Biology of the Neonate·W MacKendrickMichael S Caplan
Mar 1, 1997·Archives of Disease in Childhood. Fetal and Neonatal Edition·H KitajimaM Fujimura
Feb 1, 1997·Pediatric Surgery International·K S AzarowR M Filler
Jan 1, 1997·Indian Pediatrics·C Thomas, L Krishnan
Jan 5, 1999·Scandinavian Journal of Immunology·P NicaiseC Labarre
Nov 27, 1999·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·A B Hoyos
Feb 29, 2000·Journal of Pediatric Surgery·D J Ledbetter, S E Juul
Apr 5, 2000·Journal of Pediatric Gastroenterology and Nutrition·Michael S Caplan, Tamas Jilling
May 12, 2000·Seminars in Pediatric Surgery·J C Chandler, A Hebra
May 24, 2000·Proceedings of the National Academy of Sciences of the United States of America·N N NanthakumarW A Walker
Sep 15, 2000·Clinics in Perinatology·D J Ledbetter, S E Juul
Jun 2, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·E C Claud, W A Walker

Related Concepts

Pneumatosis Cystoides Intestinalis
Ischemia
Pathogenic Aspects
Biochemical Pathway
Necrosis
Meta-Analysis (Publications)
Electrolytes
Pathogenesis
Intestinal Gangrene
Umbilicus (Anatomy)

Related Feeds

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research
Jixin YangGail E Besner
© 2020 Meta ULC. All rights reserved