Treatment and prognostic impact of transient leukemia in neonates with Down syndrome

Blood
Jan-Henning KlusmannDirk Reinhardt

Abstract

Approximately 10% of the neonates with Down syndrome (DS) exhibit a unique transient leukemia (TL). Though TL resolves spontaneously in most patients, early death and development of myeloid leukemia (ML-DS) may occur. Prognostic factors as well as treatment indication are currently uncertain. To resolve that issue, we prospectively collected clinical, biologic, and treatment data of 146 patients with TL. The 5-year overall survival (OS) and event-free survival (EFS) were 85% plus or minus 3% and 63% plus or minus 4%, respectively. Multivariate analysis revealed a correlation between high white blood cell (WBC) count, ascites, preterm delivery, bleeding diatheses, failure of spontaneous remission, and the occurrence of early death. Treatment with cytarabine (0.5-1.5 mg/kg) was administered to 28 patients with high WBC count, thrombocytopenia, or liver dysfunction. The therapy had a beneficial effect on the outcome of those children with risk factors for early death (5-year EFS, 52% +/- 12% vs 28% +/- 11% [no treatment]; P = .02). Multivariate analysis demonstrated its favorable prognostic impact. A total of 29 (23%) patients with TL subsequently developed ML-DS. Patients with ML-DS with a history of TL had a significantly better...Continue Reading

References

Feb 1, 1997·Seminars in Perinatology·A ZipurskyJ Doyle
May 20, 1998·Genome Research·C R HeinerE Y Chen
Oct 16, 1999·The American Journal of the Medical Sciences·I OrenG Alroy
Mar 21, 2002·Journal of Pediatric Hematology/oncology·Fawaz Al-KasimUNKNOWN Pediatric Oncology Group
Aug 13, 2002·Nature Genetics·Joshua WechslerJohn D Crispino
Mar 22, 2003·British Journal of Haematology·Alvin Zipursky
May 22, 2003·Journal of Pediatric Hematology/oncology·Hart Isaacs
Jun 26, 2003·Nucleic Acids Research·Ramu ChennaJulie D Thompson
Sep 1, 1957·A.M.A. Journal of Diseases of Children·W KRIVIT, R A GOOD
May 13, 2004·European Journal of Pediatrics·Sabine DormannCharlotte Niemeyer
Feb 24, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jean-Pierre BourquinStuart H Orkin
Oct 19, 2006·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Natalia DixonSherri Zimmerman

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Citations

Sep 24, 2013·Nature Genetics·Kenichi YoshidaSeishi Ogawa
Oct 10, 2012·Proceedings of the National Academy of Sciences of the United States of America·Anindita RoyIrene Roberts
Oct 10, 2012·Proceedings of the National Academy of Sciences of the United States of America·Glenn A MacleanStuart H Orkin
Mar 20, 2009·Human Molecular Genetics·Ithamar GanmoreShai Izraeli
Jul 20, 2011·Journal of Pediatric Hematology/oncology·Brent A WilliamsJohann K Hitzler
Dec 3, 2011·Journal of Pediatric Hematology/oncology·Hiroshi KogaNoboru Takahashi
Mar 3, 2010·Genes & Development·Jan-Henning KlusmannDirk Reinhardt
Jul 19, 2013·The Journal of Clinical Investigation·Andrew J WooAlan B Cantor
Dec 7, 2013·Blood·Jeffrey W Taub
May 7, 2010·Journal of Perinatal Medicine·Arzu AkdagUğur Dilmen
Dec 14, 2011·Critical Reviews in Oncogenesis·Irum KhanJohn Crispino
Jan 30, 2009·The Oncologist·Karen R Rabin, James A Whitlock
Jan 1, 2010·The Libyan Journal of Medicine·Emily PaynePhilip Connor
Mar 7, 2014·Nature Reviews. Cancer·Glenn M MarshallWilliam A Weiss
Dec 18, 2013·International Journal of Hematology·Myoung Ja ParkYasuhide Hayashi
Apr 29, 2014·International Journal of Hematology·Francesco CorazzaAndrea Pession
Aug 21, 2013·Indian Journal of Pediatrics·Iraz NarMurat Yurdakok
Aug 13, 2013·Blood Cells, Molecules & Diseases·Irene RobertsParesh Vyas
Oct 1, 2014·Archives of Pathology & Laboratory Medicine·Melissa Bombery, Jo-Anne Vergilio
Dec 2, 2014·Pediatric Clinics of North America·Kelly W MaloneyParesh Vyas
Nov 25, 2011·European Journal of Pediatrics·Annelyse Bruwier, Christophe F Chantrain
Nov 19, 2010·Expert Review of Hematology·Ana C XavierJeffrey Taub
Jun 14, 2015·American Journal of Clinical Pathology·Sa A Wang, Robert P Hasserjian
Mar 17, 2012·Seminars in Fetal & Neonatal Medicine·Anindita RoyParesh Vyas
Oct 7, 2014·Biochimica Et Biophysica Acta·Cecilia EvangelistiAlberto M Martelli
Sep 8, 2010·Hematology/oncology Clinics of North America·Jane E Churpek, Kenan Onel
Jan 27, 2015·Pediatric Annals·Dominic O AnsariJill L O de Jong
Sep 13, 2012·British Journal of Haematology·Alan S Gamis, Franklin O Smith
Jan 19, 2012·Journal of Clinical Ultrasound : JCU·Shima Goswami, Tej Phatak
Jul 11, 2012·British Journal of Haematology·Marjolein BlinkChristian M Zwaan
Mar 17, 2010·Genes, Chromosomes & Cancer·Christa Fonatsch
Jul 10, 2009·Pediatric Blood & Cancer·Li-Bin HuangXue-Qun Luo
Feb 26, 2016·International Journal of Hematology·Satoshi Saida

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