Treatment and survival differences across tumor sites in malignant peripheral nerve sheath tumors: a SEER database analysis and review of the literature

Neuro-oncology Practice
Enrico MartinMarike L D Broekman

Abstract

Currently, literature is scarce on differences across all possible tumor sites in malignant peripheral nerve sheath tumors (MPNSTs). To determine differences in treatment and survival across tumor sites and assess possible predictors for survival, we used the Surveillance, Epidemiology, and End Results (SEER) database. MPNST cases were obtained from the SEER database. Tumor sites were recoded into: intracranial, spinal, head and neck (H&N), limbs, core (thorax/abdomen/pelvis), and unknown site of origin. Patient and tumor characteristics, treatment modalities, and survival were extracted. Overall survival (OS) was assessed using univariable and multivariable Cox regression hazard models. Kaplan-Meier survival curves were constructed per tumor site for OS and disease-specific survival (DSS). A total of 3267 MPNST patients were registered from 1973 to 2013; 167 intracranial (5.1%), 119 spinal (3.6%), 449 H&N (13.7%), 1022 limb (31.3%), 1307 core (40.0%), and 203 unknown (6.2%). The largest tumors were found in core sites (80.0 mm, interquartile range [IQR]: 60.0-115.0 mm) and the smallest were intracranial (37.4 mm, IQR: 17.3-43.5 mm). Intracranial tumors were least frequently resected (58.1%), whereas spinal tumors were most oft...Continue Reading

References

Jul 1, 1992·The American Journal of Surgical Pathology·J M MeisJ A Neal
Jan 1, 1988·Seminars in Surgical Oncology·I M Ariel
Mar 1, 1995·Annals of Surgical Oncology·J N VautheyM F Brennan
Feb 1, 1995·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·P F DoornH J Hoekstra
Feb 1, 1994·Journal of Surgical Oncology·D S VegeD M Parikh
Oct 27, 1998·International Journal of Radiation Oncology, Biology, Physics·W W WongL L Gunderson
May 16, 2002·Journal of Medical Genetics·D G R EvansA Moran
Sep 10, 2003·Neurology·Joachim M BaehringTracy T Batchelor
Sep 4, 2004·Clinical Orthopaedics and Related Research·David V CashenHenry J Mankin
Nov 19, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Modesto CarliJoern Treuner
Dec 10, 2008·The American Journal of Surgical Pathology·Bernd W ScheithauerRobert J Spinner
Jan 30, 2009·Neurosurgery·Iris C GibbsSteven A Burton
Jun 1, 2010·Human Mutation·Eric PasmantUNKNOWN members of the NF France Network
Sep 15, 2010·American Journal of Clinical Oncology·Vincent M MorettiChristian M Ogilvie
Aug 24, 2011·Annals of Surgical Oncology·Chee-Chee H StuckyNabil Wasif
Oct 28, 2011·Journal of Pediatric Hematology/oncology·Hac Ahmet DemirMünevver Büyükpamukçu
Dec 6, 2011·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Bin ZhuFeng Wei
Sep 12, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·UNKNOWN ESMO/European Sarcoma Network Working Group
Jan 30, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·T ValentinC Chevreau
Nov 12, 2016·Journal of Neurosurgery. Spine·Dean ChouUNKNOWN AOSpine Knowledge Forum Tumor
Jan 6, 2017·Cancer Research and Treatment : Official Journal of Korean Cancer Association·In Kyung HwangJung Woo Han
Mar 30, 2017·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Verena StaedtkeJaishri O'Neill Blakeley

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved