Treatment and survival of glioblastoma patients in Denmark: The Danish Neuro-Oncology Registry 2009-2014

Journal of Neuro-oncology
Steinbjørn HansenKim Oren Gradel

Abstract

As many glioblastoma patients are in a poor condition they are unable to undergo the full treatment documented in clinical trials. We aimed to examine the survival and its relationship to clinical characteristics and treatment in a nationwide population of glioblastoma patients in Denmark. We included prospectively recorded clinical data from 1364 adult patients with histologically verified glioblastoma from the Danish Neuro-Oncology Registry, 2009-2014. The age standardized incidence rate was 6.3/100,000 person-years for males and 3.9 for females and the median age was 66 years. The median overall survival was 11.2 months. There was an independently significant prognostic effect of age, performance status, cognitive symptoms, tumor diameter, multifocality, crossing midline, and contrast enhancement. For partial and total resection compared to biopsy only, the adjusted risk of dying was reduced by 43% (HR [CI] 0.57 [0.48-0.68]) and 51% (0.49 [0.40-0.60]), respectively. For patients receiving a partial and full radiochemotherapy regimen compared to no postsurgical treatment, the risk reduction was 56% (HR [CI] 0.44 [0.37-0.53]) and 70% (0.30 [0.25-0.35]), respectively. The full radiochemotherapy regimen was only allocated to 50%...Continue Reading

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Citations

Feb 23, 2019·Cell Structure and Function·Yuanyu WangBaohua Jiao
Feb 16, 2020·Journal of Neuro-oncology·Rahul RajMiikka Korja
Nov 21, 2020·Neuro-oncology Advances·Anders Rosendal KorshoejJens Christian Hedemann Sørensen
Jan 21, 2021·Brain Sciences·Donata SimińskaIrena Baranowska-Bosiacka
Mar 21, 2021·Journal of Cancer Research and Clinical Oncology·Ljupcho EfremovDaniel Medenwald
Sep 14, 2021·Acta Neurologica Scandinavica·Helena BruhnJonas Lind
Oct 12, 2021·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Danielle L WeilerJason R Powell

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