Treatment and survival of supratentorial and posterior fossa ependymomas in adults

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
Miriam NuñoChirag G Patil

Abstract

Ependymoma is a rare primary brain or spinal cord tumor that arises from the ependyma, a tissue of the central nervous system. This study analyzed a large cohort of adult supratentorial and posterior fossa ependymoma tumors in order to elucidate factors associated with overall survival. We utilized the USA National Cancer Database to study adult World Health Organization grade II/III supratentorial and posterior fossa ependymoma patients treated between 1998 and 2011. Overall survival was estimated by the Kaplan-Meier method and factors associated with survival were determined using a multivariate Cox proportional hazards model. Among 1318 patients, 1055 (80.0%) had grade II and 263 (20.0%) anaplastic tumors located in the posterior fossa (64.3%) and supratentorial region (35.7%). Overall average age was 44.3years, 48.0% of patients were female, 86.5% were Caucasian, and 36.8% underwent near/gross total surgical resection. Radiotherapy was given to 662 patients (50.8%) and 75 (5.9%) received chemotherapy. Older age at diagnosis (hazard ratio [HR] 1.51, p<0.0001), high tumor grade (HR 1.82, p=0.005), and large tumor size (HR 1.66, p=0.008) were associated with poor survival. Females compared to males (HR 0.67, p=0.03) and patien...Continue Reading

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Citations

Dec 2, 2017·Neuro-oncology·Roberta RudàElizabeth Cohen-Jonathan Moyal
Aug 9, 2020·Neuro-oncology Practice·Roshan S PrabhuStuart H Burri
Aug 7, 2019·Neuro-oncology Practice·David CachiaMark R Gilbert
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