Abstract
Using primary care data obtained from the UK Clinical Practice Research Datalink, this retrospective cohort study examined the relationships between medication adherence and clinical outcomes in patients with type 2 diabetes. Data were extracted for patients treated between 2008 and 2016, and stratified by oral antihyperglycemic agent (OHA) line of therapy (mono, dual or triple therapy). Patients were monitored for up to 365 days; associations between medication possession ratio (MPR) and outcomes at 1 year (glycated hemoglobin A1c (HbA1c), weight and hypoglycemia incidence) were assessed using linear regression modeling and descriptive analyses. In total, 33 849 patients were included in the study (n=23 925 OHA monotherapy; n=8406 OHA dual therapy; n=1518 OHA triple therapy). One-year change in HbA1c was greater among adherent (-0.90 to -1.14%; -9.8 to -12.5 mmol/mol) compared with non-adherent patients (-0.49 to -0.69%; -5.4 to -7.5 mmol/mol). On average, adherent patients had higher hypoglycemia event rates than non-adherent patients (rate ratios of 1.24, 1.10 and 2.06 for OHA mono, dual and triple therapy cohorts, respectively) and experienced greater weight change from baseline. A 10% improvement in MPR was associated with...Continue Reading
References
Aug 11, 2000·BMJ : British Medical Journal·I M StrattonR R Holman
Dec 25, 2003·Clinical Therapeutics·Rajesh BalkrishnanRoger T Anderson
Aug 31, 2004·Diabetes Care·Denys T Lau, David P Nau
Sep 16, 2004·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Louise Wood, Carlos Martinez
Jul 29, 2006·Diabetes Care·David M NathanBernard Zinman
Jan 30, 2007·Diabetes Care·Richard GrantDennis Ross-Degnan
Jan 31, 2007·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Andrew M PetersonMichael Nichol
Jan 16, 2008·Journal of the American Academy of Dermatology·Yolanda B BrauchliChristoph R Meier
Apr 30, 2008·Archives of Internal Medicine·Christian MeierChristoph R Meier
Jan 19, 2010·British Journal of Clinical Pharmacology·Emily HerrettAndrew J Hall
Mar 6, 2010·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Nada F KhanPeter W Rose
Jan 28, 2014·Current Therapeutic Research, Clinical and Experimental·Susan GrandyUNKNOWN SHIELD Study Group
May 9, 2014·Patient Preference and Adherence·Lotta WalzPer Wändell
Dec 11, 2014·Diabetes Care·Kamlesh KhuntiSanjoy K Paul
Dec 30, 2014·Diabetes Care·Silvio E InzucchiDavid R Matthews
Jan 8, 2015·Journal of Diabetes·Amy T LarkinZachary Bloomgarden
Dec 19, 2015·Diabetes Care·Andrew J FarmerAndrew T Hattersley
Oct 18, 2016·Diabetic Medicine : a Journal of the British Diabetic Association·M BaxterN Hex
Dec 28, 2016·Diabetes, Obesity & Metabolism·Jason GordonAlan Sinclair
Citations
Dec 28, 2019·Journal of Managed Care & Specialty Pharmacy·Deval GorDaniel R Touchette
Dec 15, 2019·Diabetic Medicine : a Journal of the British Diabetic Association·K WinkleyE Holmes-Truscott
Jul 26, 2019·BMJ Open·Bander BalkhiKhalid M Kamal
Aug 16, 2019·BMJ Open Diabetes Research & Care·Surendra S Borgharkar, Soma S Das
Jun 7, 2019·BMC Endocrine Disorders·Hong-Ting ZhuRu-Ying Hu
Sep 10, 2020·Obesity·Ang LiIan Caterson
May 20, 2020·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·W David StrainMarc Evans
Sep 10, 2020·JMIR Research Protocols·Yilu LinLizheng Shi
Oct 7, 2018·Journal of Endocrinological Investigation·D GiuglianoK Esposito
Aug 6, 2020·Frontiers in Cardiovascular Medicine·Benjamin A T Rodriguez, Andrew D Johnson
May 29, 2018·Journal of Diabetes·Zachary Bloomgarden
Mar 13, 2019·Frontiers in Endocrinology·Valeria RaparelliUNKNOWN EVA Collaborative Group
Dec 9, 2020·Journal of Primary Care & Community Health·Maher R KhdourDoaa H Al-Hamed
Aug 9, 2020·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Semra OzdemirSu-Yen Goh
Nov 19, 2020·Patient Preference and Adherence·Heather L GelhornAlena Strizek
Jan 13, 2021·Cardiovascular Diabetology·Dario GiuglianoKatherine Esposito
Jul 1, 2021·Diabetes, Obesity & Metabolism·Yogini V ChudasamaKamlesh Khunti
Aug 28, 2021·Journal of Basic and Clinical Physiology and Pharmacology·Shubham AtalPooja Singh
Nov 16, 2021·Diabetes, Obesity & Metabolism·Marc EvansWilliam Polonsky