Treatment decision satisfaction and regret after focal HIFU for localized prostate cancer.

World Journal of Urology
Niklas WesthoffJost von Hardenberg

Abstract

Focal therapies (FTs) are investigated within prospective studies on selected patients treated for localized prostate cancer (PCa). Benefits are preservation of genitourinary function and reduced complications, but follow-up is elaborate and is associated with uncertainty as cancer-free survival appears to be lower compared to standard radical treatments. The aim of this study was to analyse patient-reported acceptance of FT and evaluate factors associated with treatment decision regret. 52 patients who received focal high-intensity focused ultrasound for low- to intermediate-risk PCa between 2014 and 2019 within two prospective trials were eligible for a survey regarding PCa-related treatment regret and quality-of-life (Clark's scale) and the following potential predictors: sociodemographic variables, Charlson Comorbidity Index, subjective aging (AARC-10 SF), and general health-related quality-of-life (SF-12). Cancer persistence/recurrence (multiparametric MRI and fusion biopsy after 12 months) and functional outcomes (EPIC-26 UI/UIO/S) data were also included in this study. The overall survey response rate was 92.3% (48/52 patients). Median follow-up was 38 months (interquartile range = 25-50 months). In total, ten patients (...Continue Reading

References

Jan 3, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J A ClarkC M Ashton
Mar 21, 2003·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Anne E Barrett
Aug 21, 2003·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Jamie C BrehautDeb Feldman-Stewart
Oct 11, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jack A ClarkJames A Talcott
Jul 28, 2005·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·Terry Connolly, Jochen Reb
Mar 3, 2007·Psychonomic Bulletin & Review·David C Rubin, Dorthe Berntsen
Oct 21, 2009·CA: a Cancer Journal for Clinicians·Grace A LinR Adams Dudley
Jan 22, 2014·European Urology·Willemien van den BosPeter T Scardino
Dec 23, 2014·Urology·Ted A SkolarusUNKNOWN PROSTQA Consortium
Sep 7, 2016·European Urology·Massimo ValerioMark Emberton
Sep 15, 2016·The New England Journal of Medicine·Freddie C HamdyUNKNOWN ProtecT Study Group
Nov 16, 2016·Cancer Treatment Reviews·Edward J Bass, Hashim U Ahmed
May 12, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Richard M HoffmanAnn S Hamilton
May 10, 2019·World Journal of Oncology·Prashanth Rawla
Aug 15, 2019·European Urology Oncology·Giancarlo MarraLouis L Pisters

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Citations

Apr 22, 2021·World Journal of Urology·Jost von HardenbergUNKNOWN Working Group of Focal and Microtherapy of the German Society of Urology (DGU)

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Software Mentioned

R
R Foundation for Statistical Computing
JMP
REGISTER
FOXPRO

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