Treatment delays in laryngeal squamous cell carcinoma: A national cancer database analysis

The Laryngoscope
Elliot MorseSaral Mehra

Abstract

To characterize treatment delays in laryngeal cancer and associate delays with patient, tumor, and treatment factors and with overall survival. We identified 33,819 adults with laryngeal squamous cell carcinoma (LSCC) in the National Cancer Database from 2004 to 2013. We calculated durations of diagnosis-to-treatment initiation, surgery-to-adjuvant treatment, radiotherapy duration, total treatment package, and diagnosis-to-treatment end intervals. Delays were associated with patient, tumor, and treatment characteristics via multivariable logistic regression and with overall survival by Cox proportional hazards regression. Median durations of diagnosis-to-treatment initiation, surgery-to-radiation initiation, radiation treatment, total treatment package, and diagnosis-to-treatment end were 28, 42, 48, 91, and 107 days in surgical patients; median durations of diagnosis-to-treatment initiation, radiation treatment, and diagnosis-to-treatment end were 33, 50, and 85 days in nonsurgical patients. Race and insurance status were linked to delays in most intervals. Academic and high-volume facilities had less delayed radiation treatment but increased delays in most other intervals. Delayed surgery-to-radiation and total treatment pack...Continue Reading

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Citations

Mar 6, 2019·The Laryngoscope·Alexander N GoelJeffrey D Suh
Apr 17, 2020·Head & Neck·Michael C TopfJohn B Sunwoo
Oct 17, 2018·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Elliot MorseSaral Mehra
Jun 14, 2019·JAMA Otolaryngology-- Head & Neck Surgery·Sina J TorabiBenjamin L Judson
Dec 15, 2020·The Laryngoscope·Noah Z FeitAnaïs Rameau
Feb 23, 2021·Laryngoscope Investigative Otolaryngology·Daniel JacobsBenjamin L Judson
Mar 16, 2021·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Rosanne C SchoonbeekGyörgy B Halmos

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