Abstract
The aim of this study was to elucidate the regulatory responses and the long-term effect of praziquantel treatment in chronically Schistosoma bovis-infected West African Dwarf goats. Forty-two goats were used and the design comprised a primary infection followed by treatment at week 13, challenge infection at week 36 and termination at week 52. Dependent variables included clinico-pathological data, worm numbers, faecal and tissue egg counts, and gross pathology of the liver. The results showed that primary infections remained suppressed for up to 52 weeks and, although challenge infections imposed on 36-week-old primary infections established fully, the impairment of their egg production capacity provided protection against clinico-pathological consequences measured by body weight and haemoglobin levels. The study also confirmed a high efficacy (97.7%) of praziquantel for treatment of S. bovis infection in goats and showed that anthelminthic removal of primary infections does not interfere with the ability of the goat to elicit a marked resistance to a subsequent challenge infection. Although treated goats had more fibrous scarring of livers than untreated goats, no negative effects of liver lesions were reflected in weight ga...Continue Reading
References
Sep 1, 1979·Journal of Helminthology·A Bjørneboe, F Frandsen
Jan 1, 1975·American Journal of Physical Anthropology·N P Lamb
Jan 1, 1992·Memórias do Instituto Oswaldo Cruz·A M Deelder
Jan 1, 1992·Memórias do Instituto Oswaldo Cruz·A M AgnewM J Doenhoff
Jan 17, 1991·Nature·P HaganH A Wilkins
Oct 1, 1990·Acta Tropica·J MonradP Nansen
Jan 1, 1986·The American Journal of Tropical Medicine and Hygiene·A F Tawfik, D G Colley
Nov 1, 1983·The American Journal of Tropical Medicine and Hygiene·H O BusharaM G Taylor
Jan 1, 1995·Research in Veterinary Science·J MonradR Lindberg
Dec 1, 1993·Infection and Immunity·M RobertsR F Sturrock
Jul 1, 1993·Parasite Immunology·H O BusharaM G Taylor
Mar 1, 1996·Veterinary Parasitology·M V JohansenN O Christensen
Sep 1, 1996·The American Journal of Tropical Medicine and Hygiene·A AgnewA M Deelder
Jul 1, 1996·Journal of Comparative Pathology·M V JohansenR Lindberg
Aug 11, 1998·The Journal of Infectious Diseases·A MedhatC L King
Feb 13, 1999·Vaccine·D BoulangerA Capron
Nov 5, 1999·Nature Medicine·M E Woolhouse, P Hagan
Mar 2, 2002·Trends in Parasitology·F Mutapi
Sep 21, 2002·Lancet·Diana M S KaranjaW Evan Secor
Citations
Apr 18, 2013·PLoS Neglected Tropical Diseases·Bonnie L WebsterDavid Rollinson
Nov 26, 2008·Research in Veterinary Science·K SörénR Lindberg
Aug 4, 2016·Molecular and Biochemical Parasitology·Eduardo de la Torre-EscuderoAna Oleaga
Dec 24, 2021·PLoS Neglected Tropical Diseases·Julien Kincaid-SmithEve Toulza