Treatment eligibility in Alaska Native and American Indian persons with hepatitis C virus infection.

International Journal of Circumpolar Health
Stephen LivingstonDavid Gretch

Abstract

Treatment with pegylated interferon and ribavirin may prevent progression of liver disease among patients with chronic hepatitis C virus infection (HCV). Treatment initiation is based on published clinical eligibility criteria, patients' willingness to undergo treatment and likelihood of success. We examined treatment eligibility in a cohort of Alaska Native and American Indian persons with chronic HCV infection. Retrospective cohort study. Medical records of all treatment naïve HCV RNA positive patients given an appointment by hepatology specialty clinic staff in 2003 and 2007 were evaluated by a hepatology provider to investigate documented reasons for treatment deferral. Treatment was initiated in 4 of 94 patients (4%) in 2003 and 14 of 146 patients (10%) in 2007. Major reasons for treatment deferral in 2003 versus 2007 included inconsistent appointment attendance (36% of deferrals vs. 18%), active substance abuse (17% vs. 22%), patient decision (17% vs. 27%), liver biopsy without fibrosis or normal ALT (8% vs. 3%), uncontrolled psychiatric condition (7% vs. 7%) and concurrent medical condition (6% vs. 9%). There was significant improvement in proportion of appointments attended in 2007 versus 2003 (76% vs. 67%, p = 0.04) an...Continue Reading

References

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Citations

Oct 22, 2016·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Brian J McMahonPrabhu Gounder
Feb 14, 2019·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Anna E EppersonLisa Henriksen
Apr 26, 2017·Journal of Ethnicity in Substance Abuse·Melissa L WallsMichelle Sarche
May 12, 2019·Journal of Ethnicity in Substance Abuse·Stephanie AyersStephen S Kulis
Jul 11, 2013·Journal of Public Health Management and Practice : JPHMP·Brigg ReilleyRebecca Geiger
May 24, 2017·Seminars in Arthritis and Rheumatism·Elizabeth D FerucciMark H Wener

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Methods Mentioned

BETA
biopsy
biopsies

Software Mentioned

SAS

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