Treatment emergent affective switch: a controlled study

Bipolar Disorders
R S TamadaB Lafer

Abstract

To study the clinical features of treatment emergent affective switch (TEAS) in comparison with spontaneous mania. Twelve patients with TEAS within a 12-week period (average) of starting standard antidepressant medication were compared with 12 patients with spontaneous mania. Patients with TEAS were older, had longer duration of illness, more previous episodes, higher prevalence of subclinical hypothyroidism, and reported more previous episodes of mania associated with antidepressant use. TEAS was less severe, with a lower incidence of psychotic symptoms, lower Young Mania Rating Scale index score and rarely required hospitalization. The interval from intervention to response and remission was similar in both groups. TEAS was less severe, but had similar duration when compared with spontaneous mania. These results cannot directly answer the question of whether there is a causal relationship between antidepressant use and TEAS. While it is also possible that patients with longer duration of illness and higher cycle frequencies are more likely to experience episodes, it is difficult to attribute lesser severity of TEAS episodes to these clinical factors. Our observations are consistent with the suggestion that patients with longe...Continue Reading

References

Nov 1, 1978·The British Journal of Psychiatry : the Journal of Mental Science·R C YoungD A Meyer
Jul 1, 1991·The American Journal of Psychiatry·J M HimmelhochP Houck
Nov 1, 1987·The American Journal of Psychiatry·T A Wehr, F K Goodwin
Jul 1, 1980·Pharmakopsychiatrie, Neuro-Psychopharmakologie·A KukopulosL Tondo
Mar 1, 1982·Archives of General Psychiatry·J L Lewis, G Winokur
Nov 1, 1994·The American Journal of Psychiatry·A L StollM Tohen
Feb 3, 1999·European Archives of Psychiatry and Clinical Neuroscience·R BottlenderH J Möller
Mar 10, 2001·The Journal of Clinical Psychiatry·A PredaM B Bowers
May 31, 2001·The Journal of Clinical Psychiatry·C HenryM Leboyer
Sep 10, 2003·Archives of General Psychiatry·William CoryellTimothy Mueller
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON

❮ Previous
Next ❯

Citations

Sep 10, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Roy H PerlisGary S Sachs
May 25, 2010·The Journal of Clinical Psychiatry·Giacomo SalvadoreCarlos A Zarate
Jun 17, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Mehmet YumruOzcan Erel
Dec 9, 2008·Comprehensive Psychiatry·Ricardo Alexandre TonioloBeny Lafer
Nov 9, 2007·Bipolar Disorders·Michael BerkPat McGorry
Dec 14, 2007·Bipolar Disorders·Gabrielle A CarlsonEvelyn J Bromet
Jun 21, 2008·European Eating Disorders Review : the Journal of the Eating Disorders Association·Phern Chern Tor, Ee Lian Lee
Jun 20, 2006·European Psychiatry : the Journal of the Association of European Psychiatrists·M BauerP C Whybrow
Feb 24, 2006·The Journal of Pediatrics·Paul G HammernessDaniel A Geller
Mar 6, 2007·The International Journal of Neuropsychopharmacology·Guohua XiaJoseph R Calabrese

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.