Treatment for T3 to T4a laryngeal cancer by open partial horizontal laryngectomies: Prognostic impact of different pathologic tumor subcategories

Head & Neck
Giovanni SuccoGiuseppe Rizzotto

Abstract

The purpose of this retrospective study was to identify subcategories in cT3 to cT4a supraglottic/glottic cancers, describing their different spreading patterns, and local and locoregional recurrence modes. Four hundred eighty-nine patients who underwent open partial horizontal laryngectomies (OPHLs) were retrospectively classified as: subcategory I (anterior pT3 with normal arytenoid mobility); subcategory II (posterior pT3 with impaired/absent mobility); subcategory III (anterior pT4 with normal mobility); and subcategory IV (posterior pT4 with impaired/absent mobility). Five-year overall survival (OS), disease-specific survival (DSS), disease-free survival (DFS), locoregional, local control, freedom from laryngectomy, and laryngectomy-free survival were significantly better in anterior tumors (subcategories I and III) when compared with the corresponding posterior ones (subcategories II and IV). Anterior cT3 tumors are manageable by OPHL, and this approach could also be proposed in the treatment of early anterior cT4aN0. Despite promising results, OPHLs should be considered under investigation in posterior cT3 tumors due to clinical and biological behavior similar to cT4a tumors.

References

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Citations

Oct 27, 2018·The Annals of Otology, Rhinology, and Laryngology·Luca Giovanni LocatelloGiuditta Mannelli
Sep 11, 2019·Cancers·Martine HendriksmaElisabeth V Sjögren
Feb 29, 2020·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Carlos Miguel Chiesa-EstombaCesare Piazza
Sep 11, 2019·Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale·E CrosettiG Succo
May 3, 2020·Cancers·Marco BenazzoPatrizia Morbini
Jun 14, 2019·Frontiers in Oncology·Giovanni Succo, Erika Crosetti
May 30, 2020·Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale·Marco LucioniAndy Bertolin
Oct 28, 2020·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Wenfei LiZhanqiu Wang
Jan 15, 2021·American Journal of Otolaryngology·Taskin TokatGuliz Ozkok
Dec 11, 2020·Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale·Andy BertolinGiovanni Succo
Apr 27, 2021·Auris, Nasus, Larynx·Matteo FermiMatteo Alicandri-Ciufelli
Jan 4, 2022·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Marco de VincentiisRaul Pellini

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