PMID: 11312372Apr 20, 2001Paper

Treatment-induced remission in rheumatoid arthritis patients is characterized by a reduction in macrophage content of synovial biopsies

Rheumatology
M D SmithM J Ahern

Abstract

To document the change in synovial membrane macrophage and T-lymphocyte content in rheumatoid arthritis (RA) patients who achieve remission induced by disease-modifying anti-rheumatic drugs (DMARDs). Arthroscopic synovial biopsies were taken from four to seven sites around a knee joint in 13 patients with RA before and at regular intervals after commencing treatment with a DMARD. The cellular content of synovial membrane biopsies taken at regular intervals for a period of up to 3 yr after commencing treatment was quantitated by routine histopathology and immunohistochemical labelling with anti-macrophage (CD68) and anti-T lymphocyte (UCHL-1) antibodies. Synovial biopsies were quantitated with a validated semiquantitative scoring system and video image analysis. Nine patients obtained clinical remission, as defined by American College of Rheumatology (ACR) criteria. The changes that occurred in the synovial biopsies included a reduction in lining layer thickness, reduced vascularity and cellular infiltrate. The most significant reduction in cellular infiltrate was in the lining layer macrophages, with less dramatic change in the subintimal macrophage infiltrate. Although there was a reduction in CD45 Ro-positive T lymphocytes in...Continue Reading

Citations

Jun 25, 2005·Annals of the Rheumatic Diseases·M D SmithUNKNOWN OMERACT synovial special interests group
Dec 19, 2003·Arthritis Research & Therapy·Barry Bresnihan
Mar 25, 2015·Expert Opinion on Drug Metabolism & Toxicology·Anna Klukovits, Peter Krajcsi
May 1, 2009·Arthritis and Rheumatism·John A Hamilton, Paul P Tak
Oct 28, 2016·International Journal of Rheumatic Diseases·Ved ChaturvediPatrick D W Kiely
Dec 15, 2015·PloS One·Rita CascãoJoão E Fonseca
Jul 14, 2017·Nature Reviews. Rheumatology·Carl OrrSander W Tas
Oct 4, 2018·Drug Delivery and Translational Research·Durga M S H ChandrupatlaGerrit Jansen
Nov 23, 2017·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Bonnie WilliamsTania Crotti
Jun 2, 2017·Arthritis Research & Therapy·Durga M S H ChandrupatlaCarla F M Molthoff
Jan 22, 2021·Autoimmunity Reviews·Jeffrey M A van der KrogtSander W Tas
Jul 30, 2021·International Journal of Rheumatic Diseases·Robert W Ike, Kenneth C Kalunian

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