Treatment Intensification in HIV-Infected Patients Is Associated With Reduced Frequencies of Regulatory T Cells

Frontiers in Immunology
Eva M GrütznerRika Draenert

Abstract

In untreated HIV infection, the efficacy of T cell responses decreases over the disease course, resulting in disease progression. The reasons for this development are not completely understood. However, immunosuppressive cells are supposedly crucially involved. Treatment strategies to avoid the induction of these cells preserve immune functions and are therefore the object of intense research efforts. In this study, we assessed the effect of treatment intensification [=5-drug antiretroviral therapy (ART)] on the development of suppressive cell subsets. The New Era (NE) study recruited patients with primary HIV infection (PHI) or chronically HIV-infected patients with conventional ART (CHI) and applied an intensified 5-drug regimen containing maraviroc and raltegravir for several years. We compared the frequencies of the immune suppressive cells, namely, the myeloid-derived suppressor cells (MDSCs), regulatory B cells (Bregs), and regulatory T cells (Tregs), of the treatment intensification patients to the control groups, especially to the patients with conventional 3-drug ART, and analyzed the Gag/Nef-specific CD8 T cell responses. There were no differences between PHI and CHI in the NE population (p > 0.11) for any of the stud...Continue Reading

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Citations

Apr 12, 2019·Current Opinion in HIV and AIDS·Mar Naranjo-Gomez, Mireia Pelegrin
Sep 27, 2018·Frontiers in Immunology·Ziv SevilyaDavid Hassin
Aug 17, 2018·Clinical and Experimental Immunology·U Christen, E Hintermann
Aug 24, 2019·Frontiers in Immunology·Chiara AgratiAlessandra Sacchi
May 23, 2019·Frontiers in Immunology·Tandeka MagcwebebaNelita du Plessis

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Methods Mentioned

BETA
blood draw
density gradient centrifugation

Software Mentioned

GraphPad Prism
FlowJo

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