Treatment intensification without improved HbA1c levels in children and adolescents with Type 1 diabetes mellitus

Diabetic Medicine : a Journal of the British Diabetic Association
S M SildorfDanish Study Group of Diabetes in Children

Abstract

To examine trends in diabetes treatment in Danish children and adolescents with Type 1 diabetes mellitus, comparing treatment intensity with metabolic outcomes in the population, and to describe the challenges of population-based registries in a clinical setting with rapidly changing treatment methods. This observational study is based on the Danish national population registry of childhood diabetes, which includes 99% of children diagnosed with Type 1 diabetes before the age of 15 years. We included 4527 people diagnosed between 2000 and 2012. Self-monitored blood glucose measurements, insulin injections/boluses, treatment method and metabolic control quantifications were analysed and adjusted for the effects of gender and ethnicity, the combined effect of age, visit year and duration, and for the random effects of individual and hospital settings. Treatment was intensified via an increasing number of self-monitored blood glucose measurements and injections/boluses. More than six injections/boluses and an increased number of self-monitored blood glucose measurements were significantly associated with lower metabolic control. No reduction, however, in the overall mean HbA1c concentration was observed between 2005 [66 mmol/mol (...Continue Reading

References

Sep 30, 1993·The New England Journal of Medicine·UNKNOWN Diabetes Control and Complications Trial Research GroupC Siebert
Dec 31, 1997·Pediatrics·K S RutledgeS K Garg
Dec 18, 2001·The Journal of Pediatrics·N H WhiteUNKNOWN Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) Research Gro
May 15, 2002·Journal of Pediatric Endocrinology & Metabolism : JPEM·Edith SchoberUNKNOWN Pediatric Study Group of Insulin Glargine
Aug 18, 2006·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·M SchüttUNKNOWN DPV Initiative
Jan 18, 2008·Diabetic Medicine : a Journal of the British Diabetic Association·B I JakischUNKNOWN German/Austrian DPV Initiative and Working Group for Paediatric Pump Therapy
May 16, 2008·Biometrical Journal. Biometrische Zeitschrift·Torsten HothornPeter Westfall
Jan 30, 2009·Pediatric Diabetes·Jannet SvenssonUNKNOWN Danish Childhood Diabetes Registry
Sep 17, 2009·Pediatric Diabetes·Maria E CraigKim C Donaghue
Nov 15, 2011·Diabetes Care·Joachim RosenbauerUNKNOWN DPV Initiative and the German BMBF Competence Network Diabetes Mellitus
Nov 30, 2012·Diabetic Medicine : a Journal of the British Diabetic Association·M BootL M B Laffel
Jun 18, 2014·Diabetes Care·Jane L ChiangUNKNOWN Type 1 Diabetes Sourcebook Authors
Jul 22, 2014·Pediatric Diabetes·A JohansenUNKNOWN Danish Society for Diabetes in Childhood
Aug 2, 2014·Pediatric Diabetes·B OlsenUNKNOWN Danish Society for Childhood and Adolescent Diabetes
Dec 22, 2014·Acta Diabetologica·S FredheimUNKNOWN Danish Society for Diabetes in Childhood and Adolescence

❮ Previous
Next ❯

Citations

Nov 4, 2016·Pediatric Diabetes·Ulf SamuelssonLena Hanberger
Feb 28, 2018·Pediatric Diabetes·Anna Korsgaard BergJannet Svensson
Jun 18, 2021·BMC Endocrine Disorders·Jessica C G BakCarianne L Verheugt

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.