Treatment merits of Latanoprost/Thymoquinone - Encapsulated liposome for glaucomatus rabbits

International Journal of Pharmaceutics
Heba Mohamed FahmyMohamed Hassaneen Gaber

Abstract

Elevation of the intraocular pressure (IOP) is recognized as a risk factor for glaucoma development. Latanoprost (LAT) is a prostaglandin analog used to reduce the (IOP). Thymoquinone (TQ) is a major bioactive ingredient of Nigella sativa. The aim of this study was to develop novel liposomal drug carriers for ocular delivery of LAT, TQ and a mixture of them to investigate their IOP lowering efficacy upon subconjunctival injection in glaucoma-induced rabbit's eye. The aim of the present work extends also to study the effect of the different liposome formulations on the aqueous humor oxidative stress. Liposome samples were prepared using thin film hydration method. The physiochemical properties of the prepared drugs were characterized. The IOP was recorded for 70 rabbits using Schiotz-tonometer. Malondialdehyde (MDA), reduced glutathione (GSH), catalase (CAT) activities and total antioxidant activity of the aqueous humor were estimated. Fourier transform infrared and differential scanning calorimetric studies confirmed the interaction between the drug and the vesicles, which resulted in high drug encapsulation efficiency ≥88%. The size of the prepared liposomes was less than 10 μm which make them suitable in ophthalmic applicatio...Continue Reading

Citations

Nov 27, 2018·Translational Neuroscience·Qing YangLin Luo
Dec 12, 2019·Advances in Therapy·Marcelo Luís OcchiuttoAnastasios G Konstas
Aug 22, 2020·International Journal of Nanomedicine·Song KwonJong Yeon Lee
Nov 12, 2020·Journal of Clinical Medicine·Sergio Claudio SaccàAnna Maria Bassi
Sep 7, 2020·Progress in Retinal and Eye Research·Uday B KompellaMadhoosudan A Patil
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sonia TrombinoRoberta Cassano
May 15, 2021·TheScientificWorldJournal·Salima TijiMostafa Mimouni
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Mar 14, 2020·International Journal of Pharmaceutics·Suzana Gonçalves CarvalhoMarlus Chorilli
Feb 25, 2019·Life Sciences·Khushwant S YadavSushmita Sharma

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