PMID: 8580492Sep 1, 1995Paper

Treatment of 23 patients with advanced gastric cancer by intravenously transfer of autologous tumor-infiltrating lymphocytes combined with rIL-2

Chinese Medical Sciences Journal = Chung-kuo I Hsüeh K'o Hsüeh Tsa Chih
X XuQ Ni

Abstract

Tumor-infiltrating lymphocytes (TIL) isolated from metastatic lymph nodes in patients with nonoperable advanced gastric cancer were induced to become LAK-like cytotoxic activity of TIL after in vitro culture with rIL-2. Twenty-three patients with advanced gastric cancer were treated by intravenously transfer of autologous TIL combined with rIL-2. The tumor focus disappeared (complete remission, CR) in 3 patients (13.0%) and significantly decreased (partial remission, PR) in 5 patients (21.7%). Fifteen patients did not respond to the treatment. The amount of soluable IL-2 receptor in serum was significantly decreased after treatment, the cytotoxicity of NK cells and OT test were significantly increased. No significant difference in CD4/CD8 was found between before and after treatment. No serious side effect was observed in the treatment.

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Related Papers

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases
B HanM Zhou
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
D J SchwartzentruberS L Topalian
Langenbecks Archiv für Chirurgie. Supplement. Kongressband
S WimmenauerE H Farthmann
© 2021 Meta ULC. All rights reserved